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    LINC01535 long intergenic non-protein coding RNA 1535 [ Homo sapiens (human) ]

    Gene ID: 101927667, updated on 22-Oct-2024

    Summary

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    Official Symbol
    LINC01535provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1535provided by HGNC
    Primary source
    HGNC:HGNC:51282
    See related
    Ensembl:ENSG00000226686 AllianceGenome:HGNC:51282
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in thyroid (RPKM 1.7), heart (RPKM 1.4) and 14 other tissues See more
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    Genomic context

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    See LINC01535 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37251885..37265535)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39927183..39940851)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37742787..37756437)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 585B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14540 Neighboring gene zinc finger protein 383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37763986-37764523 Neighboring gene Putative uncharacterized protein PP6455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37764524-37765060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37771594-37772125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37772126-37772656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37777707-37778689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37787960-37788471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene zinc finger protein 875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC01535 promotes proliferation and inhibits apoptosis in esophageal squamous cell cancer by activating the JAK/STAT3 pathway. Fang Y, et al. Eur Rev Med Pharmacol Sci, 2020 Apr. PMID 32329845
    2. lncRNA LINC01535 upregulates BMP2 expression levels to promote osteogenic differentiation via sponging miR‑3619‑5p. Zhao Y, et al. Mol Med Rep, 2020 Dec. PMID 33174047
    3. Long non-coding RNA LINC01535 promotes cervical cancer progression via targeting the miR-214/EZH2 feedback loop. Song H, et al. J Cell Mol Med, 2019 Sep. PMID 31273925, Free PMC Article
    4. Genetics of coronary artery calcification among African Americans, a meta-analysis. Wojczynski MK, et al. BMC Med Genet, 2013 Jul 19. PMID 23870195, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA LINC01535 upregulates BMP2 expression levels to promote osteogenic differentiation via sponging miR36195p.
      Title: lncRNA LINC01535 upregulates BMP2 expression levels to promote osteogenic differentiation via sponging miR‑3619‑5p.
    2. LINC01535 promotes proliferation and inhibits apoptosis in esophageal squamous cell cancer by activating the JAK/STAT3 pathway.
      Title: LINC01535 promotes proliferation and inhibits apoptosis in esophageal squamous cell cancer by activating the JAK/STAT3 pathway.
    3. Long non-coding RNA LINC01535 promotes cervical cancer progression via targeting the miR-214/EZH2 feedback loop.
      Title: Long non-coding RNA LINC01535 promotes cervical cancer progression via targeting the miR-214/EZH2 feedback loop.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Clone Names

    • AC012309.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110718.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC016590
      Related
      ENST00000592712.5

    2. NR_110719.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC016590
      Related
      ENST00000588904.3

    3. NR_110720.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its internal exons and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC016590
      Related
      ENST00000591116.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37251885..37265535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39927183..39940851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials