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    ARHGAP33 Rho GTPase activating protein 33 [ Homo sapiens (human) ]

    Gene ID: 115703, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ARHGAP33provided by HGNC
    Official Full Name
    Rho GTPase activating protein 33provided by HGNC
    Primary source
    HGNC:HGNC:23085
    See related
    Ensembl:ENSG00000004777 MIM:614902; AllianceGenome:HGNC:23085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNX26; TCGAP; NOMA-GAP
    Summary
    This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
    Expression
    Broad expression in testis (RPKM 7.3), brain (RPKM 5.7) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP33 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35775564..35788822)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38320866..38334124)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36266466..36279724)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene proline and serine rich 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268039-36268924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268925-36269809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36275082-36275900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14503 Neighboring gene testis expressed 14B, pseudogene Neighboring gene proline dehydrogenase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36297835-36298335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nakazawa T, et al. Nat Commun, 2016 Feb 3. PMID 26839058, Free PMC Article
    2. The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42. Rosário M, et al. J Cell Biol, 2007 Jul 30. PMID 17664338, Free PMC Article
    3. The Phox homology (PX) domain, a new player in phosphoinositide signalling. Xu Y, et al. Biochem J, 2001 Dec 15. PMID 11736640, Free PMC Article
    4. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. Peck J, et al. FEBS Lett, 2002 Sep 25. PMID 12297274
    5. Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. Liu H, et al. J Biol Chem, 2006 Aug 18. PMID 16777849

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARHGAP33 is associated with brain phenotypes of patients with schizophrenia.
      Title: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.
    2. Results show that neurite outgrowth multiadaptor RhoGAP protein, NOMA-GAP, plays an essential role downstream of NGF in promoting neurite outgrowth and extension by recruiting SHP2 and activating Cdc42.
      Title: The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
    4. TCGAP interacts with Fyn and is phosphorylated by Fyn, with tyrosine-406 in the GTPase-activating protein (GAP) domain as a major Fyn-mediated phosphorylation site.
      Title: Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fibrillar center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 33
    Names
    neurite outgrowth multiadaptor RhoGAP protein
    rho-type GTPase-activating protein 33
    sorting nexin 26
    tc10/CDC42 GTPase-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172630.2 → NP_001166101.1  rho GTPase-activating protein 33 isoform 2

      See identical proteins and their annotated locations for NP_001166101.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in 5' and 3' coding regions, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, has a bigger additional segment and also lacks a smaller segment in the C-terminal region, as compared to isoform 1.
      Source sequence(s)
      AK127255, BC014084
      Consensus CDS
      CCDS54254.1
      UniProtKB/TrEMBL
      B3KU02
      Related
      ENSP00000368227.5, ENST00000378944.9
      Conserved Domains (3) summary
      cd11835
      Location:54 → 107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:175 → 369
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:1 → 32
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001366178.1 → NP_001353107.1  rho GTPase-activating protein 33 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC002398
      Consensus CDS
      CCDS92599.1
      UniProtKB/Swiss-Prot
      O14552, O14559, O14560, Q6ZSP6, Q96CP3, Q9NT23
      UniProtKB/TrEMBL
      B3KU02
      Related
      ENSP00000007510.6, ENST00000007510.9
      Conserved Domains (5) summary
      cd11835
      Location:190 → 243
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:311 → 505
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:56 → 168
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl26464
      Location:709 → 1226
      Atrophin-1; Atrophin-1 family
      cl28033
      Location:521 → 869
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    3. NM_052948.4 → NP_443180.2  rho GTPase-activating protein 33 isoform 1

      See identical proteins and their annotated locations for NP_443180.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK096338, AK127255, AL137579, BC014084, BC128586
      Consensus CDS
      CCDS12477.1
      UniProtKB/TrEMBL
      B3KU02
      Related
      ENSP00000320038.4, ENST00000314737.9
      Conserved Domains (3) summary
      cd07299
      Location:56 → 168
      PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
      cd11835
      Location:190 → 243
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:311 → 505
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35775564..35788822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722999.3 → XP_006723062.1  rho GTPase-activating protein 33 isoform X2

      UniProtKB/TrEMBL
      B3KU02
      Conserved Domains (3) summary
      cd11835
      Location:190 → 243
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:312 → 506
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:56 → 168
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_011526417.2 → XP_011524719.2  rho GTPase-activating protein 33 isoform X4

    3. XM_047438129.1 → XP_047294085.1  rho GTPase-activating protein 33 isoform X5

    4. XM_011526416.2 → XP_011524718.2  rho GTPase-activating protein 33 isoform X3

    5. XM_047438130.1 → XP_047294086.1  rho GTPase-activating protein 33 isoform X6

    6. XM_011526420.2 → XP_011524722.1  rho GTPase-activating protein 33 isoform X7

      UniProtKB/TrEMBL
      B3KU02
      Conserved Domains (3) summary
      cd11835
      Location:54 → 107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:176 → 370
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:1 → 32
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    7. XM_047438131.1 → XP_047294087.1  rho GTPase-activating protein 33 isoform X8

    8. XM_047438134.1 → XP_047294090.1  rho GTPase-activating protein 33 isoform X14

    9. XM_017026238.2 → XP_016881727.1  rho GTPase-activating protein 33 isoform X12

      UniProtKB/TrEMBL
      A0A0A0MQQ9, A1A5D2

    10. XM_011526421.3 → XP_011524723.1  rho GTPase-activating protein 33 isoform X13

      Conserved Domains (3) summary
      cd11835
      Location:227 → 280
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:349 → 543
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:93 → 205
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    11. XM_047438135.1 → XP_047294091.1  rho GTPase-activating protein 33 isoform X15

    12. XM_011526418.2 → XP_011524720.1  rho GTPase-activating protein 33 isoform X1

      UniProtKB/TrEMBL
      B3KU02
      Conserved Domains (3) summary
      cd11835
      Location:54 → 107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:176 → 370
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:1 → 32
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    13. XM_006723003.2 → XP_006723066.1  rho GTPase-activating protein 33 isoform X9

      Conserved Domains (1) summary
      PHA03247
      Location:455 → 757
      PHA03247; large tegument protein UL36; Provisional

    14. XM_047438132.1 → XP_047294088.1  rho GTPase-activating protein 33 isoform X10

    15. XM_047438133.1 → XP_047294089.1  rho GTPase-activating protein 33 isoform X11

    RNA

    1. XR_935731.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38320866..38334124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319718.1 → XP_054175693.1  rho GTPase-activating protein 33 isoform X2

    2. XM_054319720.1 → XP_054175695.1  rho GTPase-activating protein 33 isoform X4

    3. XM_054319721.1 → XP_054175696.1  rho GTPase-activating protein 33 isoform X5

    4. XM_054319719.1 → XP_054175694.1  rho GTPase-activating protein 33 isoform X3

    5. XM_054319722.1 → XP_054175697.1  rho GTPase-activating protein 33 isoform X6

    6. XM_054319723.1 → XP_054175698.1  rho GTPase-activating protein 33 isoform X7

    7. XM_054319724.1 → XP_054175699.1  rho GTPase-activating protein 33 isoform X8

    8. XM_054319729.1 → XP_054175704.1  rho GTPase-activating protein 33 isoform X14

    9. XM_054319728.1 → XP_054175703.1  rho GTPase-activating protein 33 isoform X13

    10. XM_054319730.1 → XP_054175705.1  rho GTPase-activating protein 33 isoform X15

    11. XM_054319717.1 → XP_054175692.1  rho GTPase-activating protein 33 isoform X1

    12. XM_054319725.1 → XP_054175700.1  rho GTPase-activating protein 33 isoform X9

    13. XM_054319726.1 → XP_054175701.1  rho GTPase-activating protein 33 isoform X10

    14. XM_054319727.1 → XP_054175702.1  rho GTPase-activating protein 33 isoform X11

    RNA

    1. XR_008485081.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14559.2 GenPept UniProtKB/Swiss-Prot:O14559

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