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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001319296.2 → NP_001306225.1 ankyrin repeat and SOCS box protein 8 isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
- Source sequence(s)
-
AF464877, BC001321, DA071750
- Consensus CDS
-
CCDS8761.1
- UniProtKB/Swiss-Prot
- A8K1P2, Q547Q2, Q9H765
- UniProtKB/TrEMBL
-
Q6IA19
- Conserved Domains (3) summary
-
- PHA02876
Location:26 → 215
- PHA02876; ankyrin repeat protein; Provisional
- cd03727
Location:245 → 287
- SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
- sd00045
Location:56 → 83
- ANK; ANK repeat [structural motif]
-
NM_001319297.2 → NP_001306226.1 ankyrin repeat and SOCS box protein 8 isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) lacks an alternate exon and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
- Source sequence(s)
-
AF464877, AK289957, BC001321
- Consensus CDS
-
CCDS8761.1
- UniProtKB/Swiss-Prot
- A8K1P2, Q547Q2, Q9H765
- UniProtKB/TrEMBL
-
Q6IA19
- Related
- ENSP00000445622.1, ENST00000536549.5
- Conserved Domains (3) summary
-
- PHA02876
Location:26 → 215
- PHA02876; ankyrin repeat protein; Provisional
- cd03727
Location:245 → 287
- SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
- sd00045
Location:56 → 83
- ANK; ANK repeat [structural motif]
-
NM_001319298.2 → NP_001306227.1 ankyrin repeat and SOCS box protein 8 isoform b
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR, contains an alternate exon in the 5' region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (b).
- Source sequence(s)
-
AF464877, BC001321, BP372866
- UniProtKB/Swiss-Prot
-
Q9H765
- Conserved Domains (3) summary
-
- cd03727
Location:184 → 226
- SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
- sd00045
Location:24 → 54
- ANK; ANK repeat [structural motif]
- cl39094
Location:8 → 120
- Ank_2; Ankyrin repeats (3 copies)
-
NM_001319299.2 → NP_001306228.1 ankyrin repeat and SOCS box protein 8 isoform b
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice site in the 5' UTR, contains an alternate exon in the 5' region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (b).
- Source sequence(s)
-
AF464877, BC001321, DA979010
- UniProtKB/Swiss-Prot
-
Q9H765
- Conserved Domains (3) summary
-
- cd03727
Location:184 → 226
- SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
- sd00045
Location:24 → 54
- ANK; ANK repeat [structural motif]
- cl39094
Location:8 → 120
- Ank_2; Ankyrin repeats (3 copies)
-
NM_001319300.2 → NP_001306229.1 ankyrin repeat and SOCS box protein 8 isoform c
Status: VALIDATED
- Description
- Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR and contains an alternate exon in the 3' region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter, distinct C-terminus compared to isoform a. Variants 6 and 7 encode the same isoform (c).
- Source sequence(s)
-
AF464877, BC001321, BP195070
- Consensus CDS
-
CCDS81686.1
- UniProtKB/TrEMBL
- F5GYF0, F5H772
- Related
- ENSP00000438498.1, ENST00000536953.5
- Conserved Domains (2) summary
-
- cd00204
Location:34 → 77
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- sd00045
Location:51 → 77
- ANK; ANK repeat [structural motif]
-
NM_001319301.2 → NP_001306230.1 ankyrin repeat and SOCS box protein 8 isoform c
Status: VALIDATED
- Description
- Transcript Variant: This variant (7) lacks an alternate exon and uses an alternate splice site in the 5' UTR and contains an alternate exon in the 3' region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter, distinct C-terminus compared to isoform a. Variants 6 and 7 encode the same isoform (c).
- Source sequence(s)
-
AF464877, BC001321, BP210910
- Consensus CDS
-
CCDS81686.1
- UniProtKB/TrEMBL
- F5GYF0, F5H772
- Related
- ENSP00000440773.1, ENST00000535055.5
- Conserved Domains (2) summary
-
- cd00204
Location:34 → 77
- ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
- sd00045
Location:51 → 77
- ANK; ANK repeat [structural motif]
-
NM_024095.5 → NP_077000.1 ankyrin repeat and SOCS box protein 8 isoform a
See identical proteins and their annotated locations for NP_077000.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
- Source sequence(s)
-
AF464877, BC001321, BM837218
- Consensus CDS
-
CCDS8761.1
- UniProtKB/Swiss-Prot
- A8K1P2, Q547Q2, Q9H765
- UniProtKB/TrEMBL
-
Q6IA19
- Related
- ENSP00000320893.3, ENST00000317697.8
- Conserved Domains (3) summary
-
- PHA02876
Location:26 → 215
- PHA02876; ankyrin repeat protein; Provisional
- cd03727
Location:245 → 287
- SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
- sd00045
Location:56 → 83
- ANK; ANK repeat [structural motif]
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12 Reference GRCh38.p14 Primary Assembly
- Range
-
48147789..48157515 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1 Alternate T2T-CHM13v2.0
- Range
-
48109134..48118862 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)