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    ZSCAN32 zinc finger and SCAN domain containing 32 [ Homo sapiens (human) ]

    Gene ID: 54925, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZSCAN32provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 32provided by HGNC
    Primary source
    HGNC:HGNC:20812
    See related
    Ensembl:ENSG00000140987 AllianceGenome:HGNC:20812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCCS-5; ZNF434
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.7), lymph node (RPKM 4.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZSCAN32 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3382085..3401004, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3409098..3428275, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3432085..3451004, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-ND1 pseudogene 8 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3450765-3451264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7133 Neighboring gene zinc finger protein 174 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3470303-3470585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3481451-3481952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7134 Neighboring gene zinc finger protein 597

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article
    2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Yang X, et al. Cell, 2016 Feb 11. PMID 26871637, Free PMC Article
    3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4179, FLJ20417, FLJ31901, FLJ56278

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 32
    Names
    human cervical cancer suppressor gene 5 protein
    zinc finger protein 434

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284527.2 → NP_001271456.1  zinc finger and SCAN domain-containing protein 32 isoform a

      See identical proteins and their annotated locations for NP_001271456.1

      Status: VALIDATED

      Source sequence(s)
      AK291213, AY261676
      Consensus CDS
      CCDS66921.1
      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65
      Related
      ENSP00000380061.4, ENST00000396852.9
      Conserved Domains (8) summary
      smart00431
      Location:33 → 142
      SCAN; leucine rich region
      COG5048
      Location:455 → 668
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:522 → 543
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:33 → 121
      SCAN; SCAN domain
      pfam13465
      Location:591 → 616
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:253 → 334
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:218 → 250
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. NM_001284528.2 → NP_001271457.1  zinc finger and SCAN domain-containing protein 32 isoform c

      See identical proteins and their annotated locations for NP_001271457.1

      Status: VALIDATED

      Source sequence(s)
      AK056463, AK291213, AY261676
      Consensus CDS
      CCDS66920.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Related
      ENSP00000483210.1, ENST00000618425.4
      Conserved Domains (5) summary
      COG5048
      Location:230 → 379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:233 → 254
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:302 → 327
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:1 → 45
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    3. NM_001284529.2 → NP_001271458.1  zinc finger and SCAN domain-containing protein 32 isoform c

      See identical proteins and their annotated locations for NP_001271458.1

      Status: VALIDATED

      Source sequence(s)
      AC025283, AK301586, AY261676
      Consensus CDS
      CCDS66920.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Related
      ENSP00000391787.2, ENST00000439568.2
      Conserved Domains (5) summary
      COG5048
      Location:230 → 379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:233 → 254
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:302 → 327
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:1 → 45
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    4. NM_001324340.2 → NP_001311269.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379 → 404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41 → 122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:6 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. NM_001324341.2 → NP_001311270.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379 → 404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41 → 122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:6 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. NM_001324342.2 → NP_001311271.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379 → 404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41 → 122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:6 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    7. NM_001324343.2 → NP_001311272.1  zinc finger and SCAN domain-containing protein 32 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC025283

    8. NM_001324344.2 → NP_001311273.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379 → 404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41 → 122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:6 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    9. NM_001324345.2 → NP_001311274.1  zinc finger and SCAN domain-containing protein 32 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Conserved Domains (6) summary
      COG5048
      Location:307 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379 → 404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41 → 122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:6 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    10. NM_001324346.2 → NP_001311275.1  zinc finger and SCAN domain-containing protein 32 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC025283
      Conserved Domains (7) summary
      smart00431
      Location:33 → 142
      SCAN; leucine rich region
      COG5048
      Location:382 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:450 → 470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:449 → 470
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:33 → 121
      SCAN; SCAN domain
      pfam13465
      Location:518 → 543
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:180 → 261
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    11. NM_017810.4 → NP_060280.2  zinc finger and SCAN domain-containing protein 32 isoform b

      See identical proteins and their annotated locations for NP_060280.2

      Status: VALIDATED

      Source sequence(s)
      AY261676
      Consensus CDS
      CCDS10503.1
      UniProtKB/Swiss-Prot
      Q9NX65
      Related
      ENSP00000302502.3, ENST00000304926.7
      Conserved Domains (6) summary
      COG5048
      Location:307 → 456
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:310 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:379 → 404
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:41 → 122
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:6 → 38
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3382085..3401004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023371.3 → XP_016878860.1  zinc finger and SCAN domain-containing protein 32 isoform X1

      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65
      Conserved Domains (8) summary
      smart00431
      Location:33 → 142
      SCAN; leucine rich region
      COG5048
      Location:455 → 668
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:522 → 543
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:33 → 121
      SCAN; SCAN domain
      pfam13465
      Location:591 → 616
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:253 → 334
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
      cl02581
      Location:218 → 250
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. XM_047434275.1 → XP_047290231.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3409098..3428275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380581.1 → XP_054236556.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    2. XM_054380578.1 → XP_054236553.1  zinc finger and SCAN domain-containing protein 32 isoform X3

    3. XM_054380576.1 → XP_054236551.1  zinc finger and SCAN domain-containing protein 32 isoform X1

      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65

    4. XM_054380579.1 → XP_054236554.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    5. XM_054380577.1 → XP_054236552.1  zinc finger and SCAN domain-containing protein 32 isoform X1

      UniProtKB/Swiss-Prot
      B4DWL5, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74, Q9NX65

    6. XM_054380582.1 → XP_054236557.1  zinc finger and SCAN domain-containing protein 32 isoform X4

    7. XM_054380580.1 → XP_054236555.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NX65.3 GenPept UniProtKB/Swiss-Prot:Q9NX65

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