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    CEACAM19 CEA cell adhesion molecule 19 [ Homo sapiens (human) ]

    Gene ID: 56971, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CEACAM19provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 19provided by HGNC
    Primary source
    HGNC:HGNC:31951
    See related
    Ensembl:ENSG00000186567 MIM:606691; AllianceGenome:HGNC:31951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEAL1; CEACM19
    Summary
    Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in skin (RPKM 5.4), testis (RPKM 2.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CEACAM19 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44665860..44684355)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47490642..47509104)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45169128..45187627)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45118285-45118786 Neighboring gene immunoglobulin superfamily member 23 Neighboring gene Sharpr-MPRA regulatory region 2639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14764 Neighboring gene MPRA-validated peak3503 silencer Neighboring gene PVR cell adhesion molecule Neighboring gene microRNA 4531 Neighboring gene uncharacterized LOC107985306 Neighboring gene Sharpr-MPRA regulatory region 3873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192479-45192980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45192981-45193480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45199988-45200593 Neighboring gene CEACAM16, CEACAM19 and PVR antisense RNA 1 Neighboring gene CEA cell adhesion molecule 16, tectorial membrane component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach. Zisi Z, et al. Genomics, 2020 Nov. PMID 32659328
    2. High expression of CEACAM19, a new member of carcinoembryonic antigen gene family, in patients with breast cancer. Estiar MA, et al. Clin Exp Med, 2017 Nov. PMID 27909883
    3. The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression. Michaelidou K, et al. Int J Oncol, 2013 May. PMID 23525470
    4. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. Scorilas A, et al. Gene, 2003 May 22. PMID 12801635
    5. Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-κB. Zhao H, et al. Surg Oncol, 2018 Sep. PMID 30217308

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach.
      Title: Identification and expression analysis of novel splice variants of the human carcinoembryonic antigen-related cell adhesion molecule 19 (CEACAM19) gene using a high-throughput sequencing approach.
    2. High CEACAM19 expression is associated with gastric cancer.
      Title: Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-κB.
    3. In conclusion, CEACAM19 showed high expression in tumor samples compared to normal mammary tissue.
      Title: High expression of CEACAM19, a new member of carcinoembryonic antigen gene family, in patients with breast cancer.
    4. Our results suggest that CEACAM19 mRNA expression represents a promising, novel and clinically useful tissue biomarker for breast cancer management.
      Title: The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105097

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 19
    Names
    carcinoembryonic antigen related cell adhesion molecule 19
    carcinoembryonic antigen-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127893.3 → NP_001121365.1  carcinoembryonic antigen-related cell adhesion molecule 19 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001121365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter protein (isoform 1).
      Source sequence(s)
      AC243964
      Consensus CDS
      CCDS46108.1
      UniProtKB/TrEMBL
      A0A158VUY4
      Related
      ENSP00000351627.4, ENST00000358777.10
      Conserved Domains (2) summary
      cd00096
      Location:42 → 44
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:36 → 140
      Ig; Immunoglobulin domain

    2. NM_001389722.1 → NP_001376651.1  carcinoembryonic antigen-related cell adhesion molecule 19 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC243964
      Consensus CDS
      CCDS46108.1
      UniProtKB/TrEMBL
      A0A158VUY4
      Conserved Domains (2) summary
      cd00096
      Location:42 → 44
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:36 → 140
      Ig; Immunoglobulin domain

    3. NM_020219.5 → NP_064604.2  carcinoembryonic antigen-related cell adhesion molecule 19 isoform 2 precursor

      See identical proteins and their annotated locations for NP_064604.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is longer and has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC243964
      Consensus CDS
      CCDS12641.1
      UniProtKB/Swiss-Prot
      Q5XJ15, Q7Z692, Q7Z693
      UniProtKB/TrEMBL
      A0A158VVV8
      Related
      ENSP00000384887.3, ENST00000403660.3
      Conserved Domains (1) summary
      cl11960
      Location:36 → 140
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44665860..44684355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47490642..47509104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z692.2 GenPept UniProtKB/Swiss-Prot:Q7Z692

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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