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    KRTCAP2 keratinocyte associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 200185, updated on 28-Oct-2024

    Summary

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    Official Symbol
    KRTCAP2provided by HGNC
    Official Full Name
    keratinocyte associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:28942
    See related
    Ensembl:ENSG00000163463 MIM:619029; AllianceGenome:HGNC:28942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KCP2
    Summary
    Enables enzyme activator activity. Involved in protein N-linked glycosylation. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 48.6), fat (RPKM 46.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KRTCAP2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155169408..155173304, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154309025..154312920, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155141884..155145780, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1808 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 3, regulatory Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155145543-155146051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155146052-155146560 Neighboring gene Sharpr-MPRA regulatory region 7923 Neighboring gene tripartite motif containing 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155157269-155157776 Neighboring gene mucin 1, cell surface associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma. Sun P, et al. Colloids Surf B Biointerfaces, 2023 Feb. PMID 36634487
    2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. Shrimal S, et al. J Cell Biol, 2017 Nov 6. PMID 28860277, Free PMC Article
    3. Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. Roboti P, et al. J Cell Sci, 2012 Jan 1. PMID 22266900
    4. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. Bonkobara M, et al. Br J Dermatol, 2003 Apr. PMID 12752121
    5. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. Roboti P, et al. J Cell Sci, 2012 Jul 15. PMID 22467853

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.
      Title: KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.
    2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase STT3A and the endoplasmic reticulum translocon.
      Title: DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.
    3. data strongly support the proposal that KCP2 is a newly identified subunit of the N-glycosylation machinery present in a subset of eukaryotes
      Title: Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    keratinocyte-associated protein 2
    Names
    KCP-2
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2
    keratinocytes associated protein 2
    oligosaccharyl transferase subunit KCP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173852.4 → NP_776251.2  keratinocyte-associated protein 2

      Status: VALIDATED

      Source sequence(s)
      AL607067
      Consensus CDS
      CCDS1096.2
      UniProtKB/Swiss-Prot
      B2R4Q1, Q6PG45, Q86XW2, Q8IWS4, Q8N6L1
      Related
      ENSP00000295682.5, ENST00000295682.6
      Conserved Domains (1) summary
      pfam09775
      Location:3 → 131
      Keratin_assoc; Keratinocyte-associated protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      155169408..155173304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154309025..154312920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6L1.2 GenPept UniProtKB/Swiss-Prot:Q8N6L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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