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    KIFC3 kinesin family member C3 [ Homo sapiens (human) ]

    Gene ID: 3801, updated on 28-Oct-2024

    Summary

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    Official Symbol
    KIFC3provided by HGNC
    Official Full Name
    kinesin family member C3provided by HGNC
    Primary source
    HGNC:HGNC:6326
    See related
    Ensembl:ENSG00000140859 MIM:604535; AllianceGenome:HGNC:6326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in kidney (RPKM 11.2), testis (RPKM 9.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIFC3 in Genome Data Viewer
    Location:
    16q21
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57758217..57862858, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63553374..63658232, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57792129..57837165, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 7 Neighboring gene MTCH2 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57767533-57768510 Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57777601-57778101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57790901-57791540 Neighboring gene katanin regulatory subunit B1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57808554-57809132 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57809711-57810289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57817648-57818250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57818251-57818852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57819145-57819804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57820464-57821122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57821123-57821781 Neighboring gene microRNA 6772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57828526-57829344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57829345-57830161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57835346-57836022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57836700-57837376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57850615-57851160 Neighboring gene uncharacterized LOC388282 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57858755-57859256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57859257-57859756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57869467-57869968 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57869969-57870468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57871284-57872020 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57879667-57880550 Neighboring gene RNA, U6 small nuclear 20, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57880551-57881432 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57907038-57907565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57917491-57918038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57918039-57918586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7538 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57945302-57946008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57972707-57973534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57973535-57974362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57998489-57998988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10918 Neighboring gene sperm microtubule inner protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Limited T-cell receptor diversity in liver-infiltrating lymphocytes from patients with primary biliary cirrhosis. Diu A, et al. J Autoimmun, 1993 Oct. PMID 8240664
    2. Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. Hoang EH, et al. Genomics, 1998 Sep 1. PMID 9782090
    3. Characterization of a novel C-kinesin (KIFC3) abundantly expressed in vertebrate retina and RPE. Hoang E, et al. Exp Eye Res, 1999 Jul. PMID 10375449
    4. Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. De S, et al. Cancer Res, 2009 Oct 15. PMID 19789344
    5. KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis. Nachbar J, et al. Cell Cycle, 2014. PMID 24275865, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIFC3 Regulates the progression and metastasis of gastric cancer via Notch1 pathway.
      Title: KIFC3 Regulates the progression and metastasis of gastric cancer via Notch1 pathway.
    2. Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
      Title: Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
    3. KIFC3 activity becomes the main driving force of centrosome cohesion to prevent premature spindle formation after linker dissolution as it counteracts the increasing EG5-driven pushing forces
      Title: The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly.
    4. Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C was much lower than the expression of dynactin subunits DCTN1 and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases
      Title: Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.
    5. Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47.
      Title: Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.
    6. KIFC3 may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission.
      Title: KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis.
    7. KifC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes.
      Title: Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    10. High expression of KIFC3 is associated with docetaxel resistance in breast cancer.
      Title: Overexpression of kinesins mediates docetaxel resistance in breast cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34694, DKFZp686D23201

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in zonula adherens maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in zonula adherens IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIFC3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130099.1 → NP_001123571.1  kinesin-like protein KIFC3 isoform 3

      See identical proteins and their annotated locations for NP_001123571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
      Source sequence(s)
      AK291737, BC008014, DC381406
      Consensus CDS
      CCDS45494.1
      UniProtKB/TrEMBL
      B7Z8X8
      Related
      ENSP00000396399.2, ENST00000421376.6
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. NM_001130100.2 → NP_001123572.1  kinesin-like protein KIFC3 isoform 2

      See identical proteins and their annotated locations for NP_001123572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 4.
      Source sequence(s)
      AB209290, AK291737, BC008014, DA989120
      Consensus CDS
      CCDS45493.1
      UniProtKB/TrEMBL
      B7Z808
      Related
      ENSP00000401696.2, ENST00000445690.7
      Conserved Domains (2) summary
      COG1196
      Location:172 → 444
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:443 → 770
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    3. NM_001318710.2 → NP_001305639.1  kinesin-like protein KIFC3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC092118, AK296995, BC041132, BE384068
      Consensus CDS
      CCDS81989.1
      UniProtKB/TrEMBL
      B7Z808
      Related
      ENSP00000442008.1, ENST00000541240.5
      Conserved Domains (3) summary
      COG1196
      Location:194 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:465 → 792
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam08961
      Location:153 → 186
      NRBF2; Nuclear receptor-binding factor 2, autophagy regulator

    4. NM_001318711.2 → NP_001305640.1  kinesin-like protein KIFC3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the coding region and uses an alternate start codon, compared to variant 4. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform 4.
      Source sequence(s)
      AC092118, AK291737, AK299431, BC041132
      UniProtKB/TrEMBL
      B7Z5U4, H3BMZ5
      Related
      ENSP00000454615.2, ENST00000561524.6
      Conserved Domains (3) summary
      cd01366
      Location:385 → 712
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:393 → 710
      Kinesin; Kinesin motor domain
      cl12013
      Location:119 → 306
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. NM_001318712.2 → NP_001305641.1  kinesin-like protein KIFC3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the coding region and uses an alternate start codon, compared to variant 4. It encodes isoform 6, which has a shorter and distinct N-terminus, compared to isoform 4.
      Source sequence(s)
      AK296995, AK302743, BC041132, BC047051
      Consensus CDS
      CCDS81988.1
      UniProtKB/TrEMBL
      B7Z808, F5H3M2
      Related
      ENSP00000438805.2, ENST00000540079.6
      Conserved Domains (2) summary
      cd01366
      Location:341 → 668
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      cl25732
      Location:40 → 338
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001318713.2 → NP_001305642.1  kinesin-like protein KIFC3 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon and uses an alternate splice site in the coding region, compared to variant 4. It encodes isoform 7, which is shorter than isoform 4.
      Source sequence(s)
      AK296995, AK303021, BC041132, BC047051, DC402000
      Consensus CDS
      CCDS81987.1
      UniProtKB/TrEMBL
      B7Z896, B7Z8X8
      Related
      ENSP00000444012.1, ENST00000543930.5
      Conserved Domains (2) summary
      cd01366
      Location:304 → 628
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      cl25732
      Location:3 → 301
      SMC_N; RecF/RecN/SMC N terminal domain

    7. NM_001318714.2 → NP_001305643.1  kinesin-like protein KIFC3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
      Source sequence(s)
      AK296995, BC034234, BC041132, BC047051, DC402000
      Consensus CDS
      CCDS45494.1
      UniProtKB/TrEMBL
      B7Z8X8
      Related
      ENSP00000456239.1, ENST00000562903.5
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    8. NM_001318715.2 → NP_001305644.1  kinesin-like protein KIFC3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
      Source sequence(s)
      AC092118, AK291737, BC041132, BC047051
      Consensus CDS
      CCDS45494.1
      UniProtKB/TrEMBL
      B7Z8X8
      Related
      ENSP00000454659.1, ENST00000465878.6
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    9. NM_005550.4 → NP_005541.3  kinesin-like protein KIFC3 isoform 1

      See identical proteins and their annotated locations for NP_005541.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, uses a downstream start codon and lacks an exon in the 3' coding region, compared to variant 4. It encodes isoform 1, which is shorter and has distinct N- and C-termini, compared to isoform 4.
      Source sequence(s)
      AC092118, BC001211
      Consensus CDS
      CCDS10789.2
      UniProtKB/Swiss-Prot
      A8K6S2, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6, Q9BVG8
      UniProtKB/TrEMBL
      B7Z808
      Related
      ENSP00000368976.4, ENST00000379655.8
      Conserved Domains (3) summary
      COG1196
      Location:172 → 444
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:443 → 770
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam08961
      Location:131 → 164
      NRBF2; Nuclear receptor-binding factor 2, autophagy regulator

    RNA

    1. NR_134678.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) contains multiple differences, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK295926, AK296995, BC041132, BC047051, DC402000
      Related
      ENST00000564136.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57758217..57862858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434085.1 → XP_047290041.1  kinesin-like protein KIFC3 isoform X13

    2. XM_011523075.2 → XP_011521377.1  kinesin-like protein KIFC3 isoform X8

      UniProtKB/TrEMBL
      B7Z808
      Conserved Domains (3) summary
      cd01366
      Location:492 → 819
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:500 → 817
      Kinesin; Kinesin motor domain
      cl12013
      Location:226 → 413
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_011523076.2 → XP_011521378.1  kinesin-like protein KIFC3 isoform X9

      UniProtKB/TrEMBL
      B7Z808
      Conserved Domains (3) summary
      cd01366
      Location:492 → 819
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:500 → 817
      Kinesin; Kinesin motor domain
      cl12013
      Location:226 → 413
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_005255937.2 → XP_005255994.1  kinesin-like protein KIFC3 isoform X2

      Conserved Domains (3) summary
      cd01366
      Location:606 → 933
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:614 → 931
      Kinesin; Kinesin motor domain
      cl12013
      Location:340 → 527
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_017023221.2 → XP_016878710.1  kinesin-like protein KIFC3 isoform X3

    6. XM_006721188.2 → XP_006721251.1  kinesin-like protein KIFC3 isoform X1

      Conserved Domains (3) summary
      cd01366
      Location:632 → 959
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:640 → 957
      Kinesin; Kinesin motor domain
      cl12013
      Location:366 → 553
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_047434084.1 → XP_047290040.1  kinesin-like protein KIFC3 isoform X12

      UniProtKB/Swiss-Prot
      A8K6S2, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6, Q9BVG8

    8. XM_047434080.1 → XP_047290036.1  kinesin-like protein KIFC3 isoform X5

    9. XM_011523077.2 → XP_011521379.1  kinesin-like protein KIFC3 isoform X10

      See identical proteins and their annotated locations for XP_011521379.1

      UniProtKB/TrEMBL
      B7Z808
      Conserved Domains (3) summary
      cd01366
      Location:471 → 798
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:479 → 796
      Kinesin; Kinesin motor domain
      cl12013
      Location:205 → 392
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    10. XM_047434083.1 → XP_047290039.1  kinesin-like protein KIFC3 isoform X11

    11. XM_011523078.2 → XP_011521380.1  kinesin-like protein KIFC3 isoform X16

      See identical proteins and their annotated locations for XP_011521380.1

      UniProtKB/TrEMBL
      B7Z8X8
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    12. XM_047434086.1 → XP_047290042.1  kinesin-like protein KIFC3 isoform X14

    13. XM_047434079.1 → XP_047290035.1  kinesin-like protein KIFC3 isoform X5

    14. XM_047434078.1 → XP_047290034.1  kinesin-like protein KIFC3 isoform X4

    15. XM_047434081.1 → XP_047290037.1  kinesin-like protein KIFC3 isoform X6

    16. XM_047434088.1 → XP_047290044.1  kinesin-like protein KIFC3 isoform X16

    17. XM_047434087.1 → XP_047290043.1  kinesin-like protein KIFC3 isoform X16

    18. XM_017023224.2 → XP_016878713.1  kinesin-like protein KIFC3 isoform X7

      UniProtKB/TrEMBL
      B7Z5U4

    19. XM_047434082.1 → XP_047290038.1  kinesin-like protein KIFC3 isoform X7

    20. XM_047434092.1 → XP_047290048.1  kinesin-like protein KIFC3 isoform X16

    21. XM_047434091.1 → XP_047290047.1  kinesin-like protein KIFC3 isoform X16

    22. XM_024450267.2 → XP_024306035.1  kinesin-like protein KIFC3 isoform X16

      UniProtKB/TrEMBL
      B7Z8X8
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    23. XM_024450266.2 → XP_024306034.1  kinesin-like protein KIFC3 isoform X16

      UniProtKB/TrEMBL
      B7Z8X8
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    24. XM_047434093.1 → XP_047290049.1  kinesin-like protein KIFC3 isoform X16

    25. XM_011523079.2 → XP_011521381.1  kinesin-like protein KIFC3 isoform X16

      See identical proteins and their annotated locations for XP_011521381.1

      UniProtKB/TrEMBL
      B7Z8X8
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    26. XM_047434089.1 → XP_047290045.1  kinesin-like protein KIFC3 isoform X16

    27. XM_047434090.1 → XP_047290046.1  kinesin-like protein KIFC3 isoform X16

    28. XM_024450268.2 → XP_024306036.1  kinesin-like protein KIFC3 isoform X16

      UniProtKB/TrEMBL
      B7Z8X8
      Conserved Domains (2) summary
      TIGR02168
      Location:3 → 301
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:304 → 631
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    29. XM_017023225.2 → XP_016878714.2  kinesin-like protein KIFC3 isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63553374..63658232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380295.1 → XP_054236270.1  kinesin-like protein KIFC3 isoform X13

    2. XM_054380289.1 → XP_054236264.1  kinesin-like protein KIFC3 isoform X8

    3. XM_054380290.1 → XP_054236265.1  kinesin-like protein KIFC3 isoform X9

    4. XM_054380282.1 → XP_054236257.1  kinesin-like protein KIFC3 isoform X2

    5. XM_054380283.1 → XP_054236258.1  kinesin-like protein KIFC3 isoform X3

    6. XM_054380281.1 → XP_054236256.1  kinesin-like protein KIFC3 isoform X1

    7. XM_054380286.1 → XP_054236261.1  kinesin-like protein KIFC3 isoform X5

    8. XM_054380294.1 → XP_054236269.1  kinesin-like protein KIFC3 isoform X12

      UniProtKB/Swiss-Prot
      A8K6S2, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6, Q9BVG8

    9. XM_054380291.1 → XP_054236266.1  kinesin-like protein KIFC3 isoform X10

    10. XM_054380292.1 → XP_054236267.1  kinesin-like protein KIFC3 isoform X11

    11. XM_054380299.1 → XP_054236274.1  kinesin-like protein KIFC3 isoform X16

    12. XM_054380296.1 → XP_054236271.1  kinesin-like protein KIFC3 isoform X14

    13. XM_054380285.1 → XP_054236260.1  kinesin-like protein KIFC3 isoform X5

    14. XM_054380284.1 → XP_054236259.1  kinesin-like protein KIFC3 isoform X4

    15. XM_054380287.1 → XP_054236262.1  kinesin-like protein KIFC3 isoform X6

    16. XM_054380298.1 → XP_054236273.1  kinesin-like protein KIFC3 isoform X16

    17. XM_054380293.1 → XP_054236268.1  kinesin-like protein KIFC3 isoform X7

    18. XM_054380288.1 → XP_054236263.1  kinesin-like protein KIFC3 isoform X7

    19. XM_054380303.1 → XP_054236278.1  kinesin-like protein KIFC3 isoform X16

    20. XM_054380302.1 → XP_054236277.1  kinesin-like protein KIFC3 isoform X16

    21. XM_054380308.1 → XP_054236283.1  kinesin-like protein KIFC3 isoform X16

    22. XM_054380306.1 → XP_054236281.1  kinesin-like protein KIFC3 isoform X16

    23. XM_054380305.1 → XP_054236280.1  kinesin-like protein KIFC3 isoform X16

    24. XM_054380304.1 → XP_054236279.1  kinesin-like protein KIFC3 isoform X16

    25. XM_054380301.1 → XP_054236276.1  kinesin-like protein KIFC3 isoform X16

    26. XM_054380300.1 → XP_054236275.1  kinesin-like protein KIFC3 isoform X16

    27. XM_054380307.1 → XP_054236282.1  kinesin-like protein KIFC3 isoform X16

    28. XM_054380297.1 → XP_054236272.1  kinesin-like protein KIFC3 isoform X15

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BVG8.4 GenPept UniProtKB/Swiss-Prot:Q9BVG8

    Gene LinkOut

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