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    H2BW2 H2B.W histone 2 [ Homo sapiens (human) ]

    Gene ID: 286436, updated on 2-Nov-2024

    Summary

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    Official Symbol
    H2BW2provided by HGNC
    Official Full Name
    H2B.W histone 2provided by HGNC
    Primary source
    HGNC:HGNC:27867
    See related
    Ensembl:ENSG00000101812 AllianceGenome:HGNC:27867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2BM; H2B/s; H2BFM
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. [provided by RefSeq, Nov 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See H2BW2 in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (104039956..104042454)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102437461..102439959, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103294523..103297021)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103238205-103238704 Neighboring gene uncharacterized LOC107987334 Neighboring gene H2B.W histone 1 Neighboring gene uncharacterized LOC107985662 Neighboring gene H2B.W histone 3, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Studying the Evolution of Histone Variants Using Phylogeny. Molaro A, et al. Methods Mol Biol, 2018. PMID 30073533
    2. MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones. El Kennani S, et al. Epigenetics Chromatin, 2017. PMID 28096900, Free PMC Article
    3. A unified phylogeny-based nomenclature for histone variants. Talbert PB, et al. Epigenetics Chromatin, 2012 Jun 21. PMID 22650316, Free PMC Article
    4. Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. Niture SK, et al. Biochem Biophys Res Commun, 2005 Dec 2. PMID 16226712
    5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone H2B type F-M
    Names
    H2B histone family member M
    H2B.M histone
    histone H2B.s

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164416.4 → NP_001157888.2  histone H2B type F-M

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC234782
      Consensus CDS
      CCDS55468.2
      Related
      ENSP00000347119.4, ENST00000355016.8
      Conserved Domains (1) summary
      cl23830
      Location:52 → 139
      H2B; Histone H2B

    2. NM_001388464.1 → NP_001375393.1  histone H2B type F-M

      Status: REVIEWED

      Source sequence(s)
      AC234782
      Consensus CDS
      CCDS55468.2
      Related
      ENSP00000502072.2, ENST00000675318.3
      Conserved Domains (1) summary
      cl23830
      Location:52 → 139
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      104039956..104042454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530922.3 → XP_011529224.1  histone H2B type F-M isoform X1

      See identical proteins and their annotated locations for XP_011529224.1

      UniProtKB/Swiss-Prot
      A6NP82, P0C1H6
      UniProtKB/TrEMBL
      W0TYI6
      Conserved Domains (1) summary
      cl23830
      Location:58 → 145
      H2B; Histone H2B

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102437461..102439959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326899.1 → XP_054182874.1  histone H2B type F-M isoform X2

      UniProtKB/Swiss-Prot
      A6NP82, P0C1H6
      UniProtKB/TrEMBL
      W0TYI6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001377073.1: Suppressed sequence

      Description
      NM_001377073.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1H6.2 GenPept UniProtKB/Swiss-Prot:P0C1H6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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