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    TCEAL8 transcription elongation factor A like 8 [ Homo sapiens (human) ]

    Gene ID: 90843, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TCEAL8provided by HGNC
    Official Full Name
    transcription elongation factor A like 8provided by HGNC
    Primary source
    HGNC:HGNC:28683
    See related
    Ensembl:ENSG00000180964 AllianceGenome:HGNC:28683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WEX3
    Summary
    This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 33.7), urinary bladder (RPKM 29.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCEAL8 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103252995..103255155, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101699973..101702133, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102507923..102510083, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 59 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1663 Neighboring gene brain expressed X-linked 4 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1665 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29816 Neighboring gene guanosine monophosphate reductase pseudogene Neighboring gene transcription elongation factor A like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Pillutla RC, et al. Genomics, 1999 Mar 1. PMID 10051408
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
    3. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterizes TCEAL1, another member of the human TCEAL gene family.
      Title: Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45400

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein-like 8
    Names
    TCEA-like protein 8
    transcription elongation factor A (SII)-like 8
    transcription elongation factor S-II protein-like 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016256.1 RefSeqGene

      Range
      5039..7199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001006684.2 → NP_001006685.1  transcription elongation factor A protein-like 8

      See identical proteins and their annotated locations for NP_001006685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK026349, BC035573, BU932815
      Consensus CDS
      CCDS14504.1
      UniProtKB/Swiss-Prot
      Q8IYN2
      Related
      ENSP00000353093.4, ENST00000360000.8
      Conserved Domains (1) summary
      pfam04538
      Location:1 → 113
      BEX; Brain expressed X-linked like family

    2. NM_153333.3 → NP_699164.1  transcription elongation factor A protein-like 8

      See identical proteins and their annotated locations for NP_699164.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK026349, BC035573, BU932815
      Consensus CDS
      CCDS14504.1
      UniProtKB/Swiss-Prot
      Q8IYN2
      Related
      ENSP00000361770.3, ENST00000372685.8
      Conserved Domains (1) summary
      pfam04538
      Location:1 → 113
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103252995..103255155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101699973..101702133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYN2.1 GenPept UniProtKB/Swiss-Prot:Q8IYN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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