Ap1g1 adaptor related protein complex 1 subunit gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ap1g1provided by RGD
Official Full Name: adaptor related protein complex 1 subunit gamma 1provided by RGD
Primary source: RGD:619785
See related: EnsemblRapid:ENSRNOG00000069458 AllianceGenome:RGD:619785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables collagen binding activity. Involved in synaptic vesicle budding from endosome and synaptic vesicle endocytosis. Predicted to be located in several cellular components, including cytoplasmic vesicle; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be part of AP-1 adaptor complex. Predicted to be active in presynapse. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 283.9), Adrenal (RPKM 245.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54654101..54740586)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37744633..37831134)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (41805252..41860076, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytosolic AP-1 is recruited onto the trans-Golgi network via binding to Arf-1.GTP, cargo-sorting signals and phophoinositides, where it orchestrates the assembly of clathrin-coated vesicular carriers that transport cargo molecules to endosomes.
Title: Cargo-sorting signals promote polymerization of adaptor protein-1 in an Arf-1.GTP-independent manner.
Synaptophysin and gamma-adaptin occurred in the perinuclear region of hippocampal neurons, suggesting that synaptophysin serves as a docking site for AP-1 during clathrin-dependent vesicle budding and/or kinesin-based transport reactions.
Title: Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132798 (e-PCR)
- UniSTS:216081

AI555481 (e-PCR)
- UniSTS:244016

D19Got31 (e-PCR)
- UniSTS:114230

RH124805 (e-PCR)
- UniSTS:161627

AA957928 (e-PCR)
- UniSTS:248209

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle budding from endosome	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle budding from endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AP-1 complex subunit gamma-1

Names: adaptor protein complex AP-1, gamma 1 subunit; adaptor-related protein complex 1, gamma 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393712.1 → NP_001380641.1 AP-1 complex subunit gamma-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AE72, A0A8I6ARE9

Related

ENSRNOP00000097388.1, ENSRNOT00000107107.2

Conserved Domains (4) summary

smart00809
Location:712 → 820

Alpha_adaptinC2; Adaptin C-terminal domain

pfam05109
Location:593 → 705

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:142 → 163

HEAT; HEAT repeat [structural motif]

pfam01602
Location:23 → 577

Adaptin_N; Adaptin N terminal region
NM_134460.2 → NP_604455.1 AP-1 complex subunit gamma-1 isoform 2

See identical proteins and their annotated locations for NP_604455.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AE72, B2RYN6

Related

ENSRNOP00000090346.1, ENSRNOT00000099597.2

Conserved Domains (4) summary

smart00809
Location:709 → 817

Alpha_adaptinC2; Adaptin C-terminal domain

pfam05109
Location:590 → 702

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:142 → 163

HEAT; HEAT repeat [structural motif]

pfam01602
Location:23 → 574

Adaptin_N; Adaptin N terminal region