LAYN layilin [Homo sapiens (human)] - Gene

Summary

Official Symbol: LAYNprovided by HGNC
Official Full Name: layilinprovided by HGNC
Primary source: HGNC:HGNC:29471
See related: Ensembl:ENSG00000204381 MIM:618843; AllianceGenome:HGNC:29471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables hyaluronic acid binding activity. Located in focal adhesion. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary (RPKM 7.0), thyroid (RPKM 6.2) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (111540280..111561745)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (111550425..111571891)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (111411005..111432470)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins.
Title: Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins.
Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status.
Title: Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status.
Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer.
Title: Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer.
ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis.
Title: ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis.
Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
Title: Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
Layilin augments integrin activation to promote antitumor immunity.
Title: Layilin augments integrin activation to promote antitumor immunity.
increased LAYN expression correlates with poor prognosis and increased immune infiltration levels in CD8+ T cells, CD4+ T cells, macrophages, neutrophils and DCs of multiple cancers, especially in colon and gastric cancers.
Title: LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers.
Renal biopsy samples from patients with glomerulonephritis showed high expression of LAYN in tubular epithelial cells.
Title: Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells.
results indicate that LAYN would be involved in the enhancement of inflammation and degradation of cartilage in joint diseases such as RA and OA
Title: Secretion of inflammatory factors from chondrocytes by layilin signaling.
Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin.
Title: Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	HDA more info	PubMed
NOT located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: layilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258390.2 → NP_001245319.1 layilin isoform 1 precursor

See identical proteins and their annotated locations for NP_001245319.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK055539, AK296231, AY358554, DA608521

Consensus CDS

CCDS58178.1

UniProtKB/Swiss-Prot

A6NJB0, B4DJU0, Q6UX15, Q8TAY8, Q96NC5, Q96NF3

UniProtKB/TrEMBL

B4DP26

Related

ENSP00000364765.3, ENST00000375615.7

Conserved Domains (1) summary

cd03595
Location:38 → 186

CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
NM_001258391.2 → NP_001245320.1 layilin isoform 3

See identical proteins and their annotated locations for NP_001245320.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two internal exons and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK055539, AK296231, DA608521, DB006476

Consensus CDS

CCDS58179.1

UniProtKB/Swiss-Prot

Q6UX15

Related

ENSP00000392942.2, ENST00000436913.6
NM_001318799.1 → NP_001305728.1 layilin isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK055539, AP002008, DC398135

UniProtKB/TrEMBL

B4DDS5

Conserved Domains (1) summary

cl02432
Location:1 → 34

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_178834.5 → NP_849156.1 layilin isoform 2 precursor

See identical proteins and their annotated locations for NP_849156.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK055539, AK296231, DA608521

Consensus CDS

CCDS31676.1

UniProtKB/TrEMBL

B4DP26

Related

ENSP00000364764.2, ENST00000375614.7

Conserved Domains (1) summary

cd03595
Location:30 → 178

CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin