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    NTRK3 neurotrophic receptor tyrosine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 4916, updated on 14-Nov-2024

    Summary

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    Official Symbol
    NTRK3provided by HGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:8033
    See related
    Ensembl:ENSG00000140538 MIM:191316; AllianceGenome:HGNC:8033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRKC; GP145-TrkC; gp145(trkC)
    Summary
    This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
    Expression
    Biased expression in brain (RPKM 2.8), fat (RPKM 1.2) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NTRK3 in Genome Data Viewer
    Location:
    15q25.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (87859751..88256739, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (85614323..86011407, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (88402982..88799970, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724465 Neighboring gene uncharacterized LOC124903579 Neighboring gene uncharacterized LOC124903580 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:88211934-88213133 Neighboring gene NANOG hESC enhancer GRCh37_chr15:88369377-88370100 Neighboring gene NANOG hESC enhancer GRCh37_chr15:88374259-88374825 Neighboring gene MPRA-validated peak2413 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88418072-88418572 Neighboring gene microRNA 11181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:88564569-88565768 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:88579975-88580784 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:88579163-88579974 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:88616236-88616831 Neighboring gene mediator complex subunit 28 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88784333-88784834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88798114-88798651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88798652-88799188 Neighboring gene Sharpr-MPRA regulatory region 8091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88817782-88818282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:88818283-88818783 Neighboring gene uncharacterized LOC105370957 Neighboring gene uncharacterized LOC105370958 Neighboring gene NTRK3 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Braskie MN, et al. Neuroimage, 2013 Nov 15. PMID 23727532, Free PMC Article
    2. Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. Gruber-Olipitz M, et al. Electrophoresis, 2009 Feb. PMID 19156760
    3. Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. Weinkauf C, et al. Infect Immun, 2009 Apr. PMID 19179422, Free PMC Article
    4. Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot. Kong B, et al. Chin Med J (Engl), 2009 Jan 20. PMID 19187638
    5. Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. Otnaess MK, et al. Neurobiol Dis, 2009 Jun. PMID 19344762

    See all (205) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.
      Title: NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas.
    2. Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
      Title: Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
    3. Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
      Title: Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
    4. High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology.
      Title: High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology.
    5. TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
      Title: TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation.
    6. Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile.
      Title: Prediction of EVT6-NTRK3-Dependent Papillary Thyroid Cancer Using Minor Expression Profile.
    7. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
      Title: Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
    8. An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.
      Title: An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma.
    9. [Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].
      Title: [Clinicopathological features of NTRK3 gene rearrangement papillary thyroid carcinoma].
    10. Fluorescent In Situ Hybridization Must be Preferred to pan-TRK Immunohistochemistry to Diagnose NTRK3-rearranged Gastrointestinal Stromal Tumors (GIST).
      Title: Fluorescent In Situ Hybridization Must be Preferred to pan-TRK Immunohistochemistry to Diagnose NTRK3-rearranged Gastrointestinal Stromal Tumors (GIST).
    Submit: New GeneRIF Correction See all GeneRIFs (130)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotrophin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotrophin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotrophin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to nerve growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotrophin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NT-3 growth factor receptor
    Names
    ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
    ETV6-NTRK3 fusion
    neurotrophic tyrosine kinase, receptor, type 3
    tyrosine kinase receptor C
    NP_001007157.1
    NP_001012338.1
    NP_001230030.1
    NP_001307063.1
    NP_001307064.1
    NP_001362739.1
    NP_001362740.1
    NP_001362741.1
    NP_001362742.1
    NP_001362743.1
    NP_002521.2
    XP_006720608.1
    XP_006720611.1
    XP_006720612.1
    XP_006720613.1
    XP_011519940.1
    XP_016877729.1
    XP_016877730.1
    XP_016877731.1
    XP_016877732.1
    XP_016877733.1
    XP_016877734.1
    XP_016877739.1
    XP_016877740.1
    XP_016877741.1
    XP_016877743.1
    XP_024305702.1
    XP_024305703.1
    XP_047288558.1
    XP_047288559.1
    XP_047288560.1
    XP_054234029.1
    XP_054234030.1
    XP_054234031.1
    XP_054234032.1
    XP_054234033.1
    XP_054234034.1
    XP_054234035.1
    XP_054234036.1
    XP_054234037.1
    XP_054234038.1
    XP_054234039.1
    XP_054234040.1
    XP_054234041.1
    XP_054234042.1
    XP_054234043.1
    XP_054234044.1
    XP_054234045.1
    XP_054234046.1
    XP_054234047.1
    XP_054234048.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029619.2 RefSeqGene

      Range
      5000..401988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007156.3 → NP_001007157.1  NT-3 growth factor receptor isoform c precursor

      See identical proteins and their annotated locations for NP_001007157.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC009711, AC021677
      Consensus CDS
      CCDS32323.1
      UniProtKB/TrEMBL
      Q96CY4, X5DP84
      Related
      ENSP00000318328.3, ENST00000317501.9
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_001012338.3 → NP_001012338.1  NT-3 growth factor receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001012338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS32322.1
      UniProtKB/Swiss-Prot
      B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16288, Q16289
      UniProtKB/TrEMBL
      H0YM90, X5D2R1
      Related
      ENSP00000485864.1, ENST00000629765.3
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:532 → 832
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. NM_001243101.2 → NP_001230030.1  NT-3 growth factor receptor isoform d precursor

      See identical proteins and their annotated locations for NP_001230030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but lacks two alternate internal segments compared to isoform a.
      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS58399.1
      UniProtKB/TrEMBL
      H0YM90, X5DNW6
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:524 → 810
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    4. NM_001320134.1 → NP_001307063.1  NT-3 growth factor receptor isoform e precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC021677, AF058390, AK309695, BM675026, S76476
      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    5. NM_001320135.2 → NP_001307064.1  NT-3 growth factor receptor isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding and non-coding regions, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform f) has a shorter N-terminus and a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS81916.1
      UniProtKB/TrEMBL
      B7Z7U4, H0YM90
      Related
      ENSP00000437773.2, ENST00000542733.6
      Conserved Domains (7) summary
      cd04971
      Location:221 → 298
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:113 → 203
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00410
      Location:120 → 203
      IG_like; Immunoglobulin like
      sd00031
      Location:7 → 30
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:5 → 62
      LRR_8; Leucine rich repeat
      pfam16920
      Location:65 → 110
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21453
      Location:434 → 614
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001375810.1 → NP_001362739.1  NT-3 growth factor receptor isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS32322.1
      UniProtKB/Swiss-Prot
      B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16288, Q16289
      UniProtKB/TrEMBL
      H0YM90, X5D2R1
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:532 → 832
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    7. NM_001375811.1 → NP_001362740.1  NT-3 growth factor receptor isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS10340.1
      UniProtKB/TrEMBL
      H0YM90, X5D7M5
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:532 → 818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    8. NM_001375812.1 → NP_001362741.1  NT-3 growth factor receptor isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS58399.1
      UniProtKB/TrEMBL
      H0YM90, X5DNW6
      Related
      ENSP00000453959.1, ENST00000557856.5
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:524 → 810
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    9. NM_001375813.1 → NP_001362742.1  NT-3 growth factor receptor isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC009711, AC021677
      Consensus CDS
      CCDS32323.1
      UniProtKB/TrEMBL
      Q96CY4, X5DP84
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    10. NM_001375814.1 → NP_001362743.1  NT-3 growth factor receptor isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      AC009711, AC021677
      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    11. NM_002530.4 → NP_002521.2  NT-3 growth factor receptor isoform b precursor

      See identical proteins and their annotated locations for NP_002521.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AC009711, AC011966, AC021677
      Consensus CDS
      CCDS10340.1
      UniProtKB/TrEMBL
      H0YM90, X5D7M5
      Related
      ENSP00000377990.1, ENST00000394480.6
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:532 → 818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      87859751..88256739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022240.2 → XP_016877729.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      H0YM90, X5D7M5
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:532 → 818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. XM_017022254.3 → XP_016877743.1  NT-3 growth factor receptor isoform X18

      UniProtKB/TrEMBL
      H0YM90
      Conserved Domains (8) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00219
      Location:538 → 835
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:218 → 301
      IG_like; Immunoglobulin like
      cd05094
      Location:532 → 843
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. XM_017022244.3 → XP_016877733.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      H0YM90

    4. XM_017022245.3 → XP_016877734.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      H0YM90

    5. XM_017022243.2 → XP_016877732.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      H0YM90

    6. XM_017022241.2 → XP_016877730.1  NT-3 growth factor receptor isoform X2

      UniProtKB/TrEMBL
      H0YM90

    7. XM_017022252.3 → XP_016877741.1  NT-3 growth factor receptor isoform X17

    8. XM_017022251.3 → XP_016877740.1  NT-3 growth factor receptor isoform X16

    9. XM_006720545.5 → XP_006720608.1  NT-3 growth factor receptor isoform X5

      UniProtKB/TrEMBL
      H0YM90
      Related
      ENSP00000453511.1, ENST00000558676.5
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00410
      Location:218 → 301
      IG_like; Immunoglobulin like
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21453
      Location:532 → 712
      PKc_like; Protein Kinases, catalytic domain

    10. XM_017022242.3 → XP_016877731.1  NT-3 growth factor receptor isoform X3

      UniProtKB/TrEMBL
      H0YM90

    11. XM_047432603.1 → XP_047288559.1  NT-3 growth factor receptor isoform X8

    12. XM_047432602.1 → XP_047288558.1  NT-3 growth factor receptor isoform X7

      Related
      ENSP00000511943.1, ENST00000695463.1

    13. XM_024449934.2 → XP_024305702.1  NT-3 growth factor receptor isoform X6

      UniProtKB/TrEMBL
      Q96CY4, X5DP84
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    14. XM_024449935.2 → XP_024305703.1  NT-3 growth factor receptor isoform X9

      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (5) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    15. XM_006720548.5 → XP_006720611.1  NT-3 growth factor receptor isoform X10

      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218 → 301
      IG_like; Immunoglobulin like
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    16. XM_006720550.5 → XP_006720613.1  NT-3 growth factor receptor isoform X12

      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218 → 301
      IG_like; Immunoglobulin like
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    17. XM_006720549.5 → XP_006720612.1  NT-3 growth factor receptor isoform X11

      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218 → 301
      IG_like; Immunoglobulin like
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    18. XM_011521638.4 → XP_011519940.1  NT-3 growth factor receptor isoform X14

      UniProtKB/TrEMBL
      X5DP84
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:218 → 301
      IG_like; Immunoglobulin like
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    19. XM_047432604.1 → XP_047288560.1  NT-3 growth factor receptor isoform X15

    20. XM_017022250.3 → XP_016877739.1  NT-3 growth factor receptor isoform X13

      UniProtKB/TrEMBL
      X5DP84

    RNA

    1. XR_001751292.3 RNA Sequence

    2. XR_002957645.2 RNA Sequence

    3. XR_001751293.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      85614323..86011407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378054.1 → XP_054234029.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      X5D7M5

    2. XM_054378073.1 → XP_054234048.1  NT-3 growth factor receptor isoform X18

    3. XM_054378057.1 → XP_054234032.1  NT-3 growth factor receptor isoform X4

    4. XM_054378059.1 → XP_054234034.1  NT-3 growth factor receptor isoform X4

    5. XM_054378058.1 → XP_054234033.1  NT-3 growth factor receptor isoform X4

    6. XM_054378055.1 → XP_054234030.1  NT-3 growth factor receptor isoform X2

    7. XM_054378072.1 → XP_054234047.1  NT-3 growth factor receptor isoform X17

    8. XM_054378071.1 → XP_054234046.1  NT-3 growth factor receptor isoform X16

    9. XM_054378060.1 → XP_054234035.1  NT-3 growth factor receptor isoform X5

    10. XM_054378056.1 → XP_054234031.1  NT-3 growth factor receptor isoform X3

    11. XM_054378063.1 → XP_054234038.1  NT-3 growth factor receptor isoform X8

    12. XM_054378062.1 → XP_054234037.1  NT-3 growth factor receptor isoform X7

    13. XM_054378061.1 → XP_054234036.1  NT-3 growth factor receptor isoform X6

      UniProtKB/TrEMBL
      Q96CY4

    14. XM_054378064.1 → XP_054234039.1  NT-3 growth factor receptor isoform X9

    15. XM_054378065.1 → XP_054234040.1  NT-3 growth factor receptor isoform X10

    16. XM_054378067.1 → XP_054234042.1  NT-3 growth factor receptor isoform X12

    17. XM_054378066.1 → XP_054234041.1  NT-3 growth factor receptor isoform X11

    18. XM_054378069.1 → XP_054234044.1  NT-3 growth factor receptor isoform X14

    19. XM_054378070.1 → XP_054234045.1  NT-3 growth factor receptor isoform X15

    20. XM_054378068.1 → XP_054234043.1  NT-3 growth factor receptor isoform X13

    RNA

    1. XR_008488951.1 RNA Sequence

    2. XR_008488953.1 RNA Sequence

    3. XR_008488952.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16288.2 GenPept UniProtKB/Swiss-Prot:Q16288

    Gene LinkOut

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