Fcgr3 Fc receptor, IgG, low affinity III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcgr3provided by MGI
Official Full Name: Fc receptor, IgG, low affinity IIIprovided by MGI
Primary source: MGI:MGI:95500
See related: Ensembl:ENSMUSG00000059498 AllianceGenome:MGI:95500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD16
Summary: Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc gamma receptor IIa). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in placenta adult (RPKM 18.3), testis adult (RPKM 15.7) and 27 other tissues See more
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Genomic context

Location:: 1 H3; 1 78.8 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (170878738..170893477, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171051169..171065915, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5.
Title: Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5.
Impact of surface receptors TLR2, CR3, and FcgammaRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
Title: Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
Role of FcgammaRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model.
Title: Role of FcγRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model.
The CD3zeta adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
Title: The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.
Title: FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.
Although enhanced humoral immune responses were observed in the absence of FcgammaRIIIA in the mouse asthma model, no overall regulation by FcgammaRIIIA, especially in terms of those parameters measuring lung tissue inflammation, was recorded. In the absence of FcgammaRIIB, augmented immune responses measured as serum antibody levels as well as those in various regulatory pathways in this mouse asthma model were observed.
Title: FcγRIIIA Negatively Impacts Humoral Immune Responses but Not Overall Lung Inflammation in an Ovalbumin-Induced Allergic Asthma Mouse Model.
FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
Title: Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes.
PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor-mediated phagocytosis in macrophages.
Title: Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.
Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression.
Title: MafB enhances the phagocytic activity of RAW264.7 macrophages by promoting Fcgr3 expression.
Fcgr3 resided in Kupffer cells, and it contributed to the inhibition of the growth of liver tumor cells.
Title: Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (8) 1 citation

General gene information

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Markers

M14215 (e-PCR)
- UniSTS:178510

Fcgr3 (e-PCR), detects polymorphism
- UniSTS:143084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgG receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables IgG receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mast cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type I hypersensitivity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type I hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type III hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within serotonin secretion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor III

Names: Fc gamma receptor III; Fcg receptor III; FcgammaRIII; fc-gamma RIII; fcRIII; igG Fc receptor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356511.2 → NP_001343440.1 low affinity immunoglobulin gamma Fc region receptor III isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC115959, AC117796

Consensus CDS

CCDS87919.1

UniProtKB/TrEMBL

E9PUV2, Q9ES92

Related

ENSMUSP00000131836.2, ENSMUST00000169017.8

Conserved Domains (2) summary

cd05753
Location:122 → 204

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cl11960
Location:40 → 118

Ig; Immunoglobulin domain
NM_001405018.1 → NP_001391947.1 low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC115959, AC117796

UniProtKB/TrEMBL

A0A0B4J1M6
NM_001405019.1 → NP_001391948.1 low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC115959, AC117796

UniProtKB/TrEMBL

A0A0B4J1M6
NM_010188.5 → NP_034318.2 low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

See identical proteins and their annotated locations for NP_034318.2

Status: VALIDATED

Source sequence(s)

AC115959, AK151557, BY199827

Consensus CDS

CCDS15477.2

UniProtKB/TrEMBL

A0A0B4J1M6, Q9ES92

Related

ENSMUSP00000131938.2, ENSMUST00000164044.8

Conserved Domains (2) summary

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cl11960
Location:41 → 119

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

170878738..170893477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496659.5 → XP_006496722.1 low affinity immunoglobulin gamma Fc region receptor III isoform X1

See identical proteins and their annotated locations for XP_006496722.1

UniProtKB/TrEMBL

A0A0B4J1M6, Q9ES92

Conserved Domains (2) summary

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cl11960
Location:41 → 119

Ig; Immunoglobulin domain
XM_030247708.1 → XP_030103568.1 low affinity immunoglobulin gamma Fc region receptor III isoform X1

UniProtKB/TrEMBL

A0A0B4J1M6, Q9ES92

Conserved Domains (2) summary

cd05753
Location:123 → 205

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cl11960
Location:41 → 119

Ig; Immunoglobulin domain