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    SIGLEC7 sialic acid binding Ig like lectin 7 [ Homo sapiens (human) ]

    Gene ID: 27036, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SIGLEC7provided by HGNC
    Official Full Name
    sialic acid binding Ig like lectin 7provided by HGNC
    Primary source
    HGNC:HGNC:10876
    See related
    Ensembl:ENSG00000168995 MIM:604410; AllianceGenome:HGNC:10876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
    Summary
    Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in spleen (RPKM 7.6), appendix (RPKM 5.3) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SIGLEC7 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51142301..51153526)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54230909..54242134)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51645558..51656783)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene sialic acid binding Ig like lectin 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15009 Neighboring gene uncharacterized LOC124904749 Neighboring gene uncharacterized LOC101928517 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51660802-51661000 Neighboring gene Sharpr-MPRA regulatory region 7523 Neighboring gene sialic acid binding Ig like lectin 17, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51684473-51685444 Neighboring gene sialic acid binding Ig like lectin 20, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA methylation-mediated Siglec-7 regulation in natural killer cells via two 5' promoter CpG sites. Huang HT, et al. Immunology, 2020 May. PMID 32027025, Free PMC Article
    2. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. Attrill H, et al. Biochem J, 2006 Jul 15. PMID 16623661, Free PMC Article
    3. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. Brunetta E, et al. Blood, 2009 Oct 29. PMID 19710502, Free PMC Article
    4. Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. Dimasi N, et al. Acta Crystallogr D Biol Crystallogr, 2004 Feb. PMID 14747738
    5. Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. Varchetta S, et al. PLoS One, 2012. PMID 23029261, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of SIGLEC7 may promote M2-type macrophage polarization leading to adverse prognosis in glioma patients.
      Title: High expression of SIGLEC7 may promote M2-type macrophage polarization leading to adverse prognosis in glioma patients.
    2. The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
      Title: The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
    3. Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release.
      Title: Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release.
    4. Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities.
      Title: Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities.
    5. Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.
      Title: Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.
    6. Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
      Title: Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
    7. Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia.
      Title: Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia.
    8. Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.
      Title: Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.
    9. Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7.
      Title: Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7.
    10. Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
      Title: Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SIGLEC7 binds to HIV-1 gp120 and enhances HIV-1 infection of CD4+ T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sialic acid-binding Ig-like lectin 7
    Names
    QA79 membrane protein
    adhesion inhibitory receptor molecule 1, siglec-7
    sialic acid binding immunoglobulin-like lectin 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277201.2 → NP_001264130.1  sialic acid-binding Ig-like lectin 7 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001264130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks all internal coding exons, compared to variant 1. The resulting isoform (3) is C-terminal truncated, compared to isoform 1.
      Source sequence(s)
      AJ007395, AJ130713, BX644517
      Consensus CDS
      CCDS62771.1
      UniProtKB/Swiss-Prot
      Q9Y286
      Related
      ENSP00000472529.1, ENST00000600577.1
      Conserved Domains (2) summary
      cd05712
      Location:26 → 144
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:31 → 122
      IG_like; Immunoglobulin like

    2. NM_014385.4 → NP_055200.1  sialic acid-binding Ig-like lectin 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_055200.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC063977
      Consensus CDS
      CCDS12826.1
      UniProtKB/Swiss-Prot
      Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y286, Q9Y502
      Related
      ENSP00000323328.6, ENST00000317643.10
      Conserved Domains (3) summary
      cd05712
      Location:26 → 144
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:261 → 336
      IG_like; Immunoglobulin like
      cl11960
      Location:150 → 223
      Ig; Immunoglobulin domain

    3. NM_016543.4 → NP_057627.2  sialic acid-binding Ig-like lectin 7 isoform 2 precursor

      See identical proteins and their annotated locations for NP_057627.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AJ007395, AJ130711, BX644517
      Consensus CDS
      CCDS42601.1
      UniProtKB/Swiss-Prot
      Q9Y286
      Related
      ENSP00000306757.6, ENST00000305628.7
      Conserved Domains (3) summary
      cd05712
      Location:26 → 144
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:168 → 243
      IG_like; Immunoglobulin like
      pfam13895
      Location:167 → 245
      Ig_2; Immunoglobulin domain

    RNA

    1. NR_102350.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AJ007395, AJ130712

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51142301..51153526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526721.4 → XP_011525023.1  sialic acid-binding Ig-like lectin 7 isoform X1

      Conserved Domains (3) summary
      cd05712
      Location:26 → 144
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:152 → 227
      IG_like; Immunoglobulin like
      pfam13895
      Location:151 → 229
      Ig_2; Immunoglobulin domain

    2. XM_047438604.1 → XP_047294560.1  sialic acid-binding Ig-like lectin 7 isoform X2

    3. XM_047438605.1 → XP_047294561.1  sialic acid-binding Ig-like lectin 7 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54230909..54242134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320538.1 → XP_054176513.1  sialic acid-binding Ig-like lectin 7 isoform X1

    2. XM_054320539.1 → XP_054176514.1  sialic acid-binding Ig-like lectin 7 isoform X2

    3. XM_054320540.1 → XP_054176515.1  sialic acid-binding Ig-like lectin 7 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y286.1 GenPept UniProtKB/Swiss-Prot:Q9Y286

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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