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    GIMAP1 GTPase, IMAP family member 1 [ Homo sapiens (human) ]

    Gene ID: 170575, updated on 2-Nov-2024

    Summary

    Official Symbol
    GIMAP1provided by HGNC
    Official Full Name
    GTPase, IMAP family member 1provided by HGNC
    Primary source
    HGNC:HGNC:23237
    See related
    Ensembl:ENSG00000213203 MIM:608084; AllianceGenome:HGNC:23237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IAN2; IMAP1; HIMAP1; IMAP38
    Summary
    This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec 2010]
    Expression
    Broad expression in spleen (RPKM 16.0), lymph node (RPKM 10.4) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GIMAP1 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150716613..150724284)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151889523..151897194)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150413701..150421372)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901774 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26841 Neighboring gene GTPase, IMAP family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150403727-150404226 Neighboring gene GIMAP1-GIMAP5 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:150432641-150433627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26843 Neighboring gene GTPase, IMAP family member 5 Neighboring gene GTPase, IMAP family member 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: GIMAP2

    Readthrough GIMAP1-GIMAP5

    Readthrough gene: GIMAP1-GIMAP5, Included gene: GIMAP5

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GTPase IMAP family member 1
    Names
    immune-associated nucleotide-binding protein 2
    immunity associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130759.4NP_570115.1  GTPase IMAP family member 1

      See identical proteins and their annotated locations for NP_570115.1

      Status: REVIEWED

      Source sequence(s)
      AC006479, AW029312, BC040736, DA817535
      Consensus CDS
      CCDS5906.1
      UniProtKB/Swiss-Prot
      B2RCI3, Q8NAZ0, Q8WWP7
      UniProtKB/TrEMBL
      A0A090N8Z4
      Related
      ENSP00000302833.5, ENST00000307194.6
      Conserved Domains (1) summary
      cd01852
      Location:28229
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150716613..150724284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151889523..151897194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)