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    ZNF852 zinc finger protein 852 [ Homo sapiens (human) ]

    Gene ID: 285346, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF852provided by HGNC
    Official Full Name
    zinc finger protein 852provided by HGNC
    Primary source
    HGNC:HGNC:27713
    See related
    Ensembl:ENSG00000178917 AllianceGenome:HGNC:27713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Ubiquitous expression in prostate (RPKM 1.1), spleen (RPKM 1.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF852 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44491766..44510617, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44507580..44526413, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44533258..44552109, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 694 Neighboring gene zinc finger protein 445 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44482886-44483092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14264 Neighboring gene uncharacterized LOC101928529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44551492-44552268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44552269-44553045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19766 Neighboring gene zinc finger protein 852 pseudogene Neighboring gene EI24 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells. Ke C, et al. Cell Biol Int, 2022 Apr. PMID 34957631
    2. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells.
      Title: Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 852
    Names
    putative zinc finger protein 852

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287349.3 → NP_001274278.1  zinc finger protein 852 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the same splice pattern as variant 1, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (3) has a frameshifted C-terminus, compared to isoform 1.
      Source sequence(s)
      AC099669, AK296954
      UniProtKB/Swiss-Prot
      Q6ZMS4

    2. NM_001423469.1 → NP_001410398.1  zinc finger protein 852 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the allele encoded by the reference genome (GRCh38) and encodes isoform 1.
      Source sequence(s)
      AC099669
      UniProtKB/Swiss-Prot
      B4DLD7, Q6ZMS4
      Related
      ENSP00000389841.2, ENST00000436261.7

    3. NM_001423470.1 → NP_001410399.1  zinc finger protein 852 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the allele encoded by the reference genome (GRCh38) and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is one amino acid longer than isoform 1.
      Source sequence(s)
      AC099669
      Related
      ENSP00000520482.1, ENST00000715584.1

    4. NM_001423484.1 → NP_001410413.1  zinc finger protein 852 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the same splice pattern as variant 2, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (4) has a frameshifted C-terminus, compared to isoform 2.
      Source sequence(s)
      AC099669, AK296954
      UniProtKB/TrEMBL
      A0AAQ5BIJ6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44491766..44510617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      17120..35971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44507580..44526413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMS4.4 GenPept UniProtKB/Swiss-Prot:Q6ZMS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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