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    PF3D7_1108600 endoplasmic reticulum-resident calcium binding protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 810649, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1108600
    Gene description
    endoplasmic reticulum-resident calcium binding protein
    Locus tag
    PF3D7_1108600
    See related
    PlasmoDB:PF3D7_1108600; VEuPathDB:PF3D7_1108600
    Gene type
    protein coding
    RNA name
    endoplasmic reticulum-resident calcium binding protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1108600 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    1
    Sequence:
    Chromosome: 11; NC_037282.1 (369675..370706, complement)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha subunit Neighboring gene succinyl-CoA synthetase alpha subunit, putative Neighboring gene heat shock protein J2 Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Endoplasmic Reticulum CREC Family Protein Regulates the Egress Proteolytic Cascade in Malaria Parasites. Fierro MA, et al. mBio, 2020 Feb 25. PMID 32098818, Free PMC Article
    2. Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251. Morita M, et al. J Proteome Res, 2012 Dec 7. PMID 23061985
    3. Identification of an endoplasmic reticulum-resident calcium-binding protein with multiple EF-hand motifs in asexual stages of Plasmodium falciparum. La Greca N, et al. Mol Biochem Parasitol, 1997 Nov. PMID 9364972
    4. The endoplasmic reticulum-resident serpentine receptor SR10 has important functions for asexual and sexual blood stage development of Plasmodium falciparum. Njila Tchoufack EJ, et al. Mol Biochem Parasitol, 2020 Sep. PMID 32890576
    5. Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, et al. Proteomics Clin Appl, 2008 Sep. PMID 21136929

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P. falciparum endoplasmic reticulum-resident calcium binding protein (PfERC) was decreased by treatment with antimalarial endoperoxides.
      Title: Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in food vacuole HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    endoplasmic reticulum-resident calcium binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      369675..370706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347737.1 → XP_001347773.1  endoplasmic reticulum-resident calcium binding protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001347773.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V5X3, A0A024VJ68, A0A024WP80, A0A024X6Y4, A0A0L1IF83, A0A0L7KHW3, Q25793, Q8IIR7, W4IF36, W4ITN5, W7FDY6, W7G3V3, W7JT70
      Conserved Domains (1) summary
      cl25354
      Location:60 → 235
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    Nucleotide Protein
    Heading Accession and Version

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