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    PF3D7_1116800 heat shock protein 101 [ Plasmodium falciparum 3D7 ]

    Gene ID: 810722, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1116800
    Gene description
    heat shock protein 101
    Locus tag
    PF3D7_1116800
    See related
    PlasmoDB:PF3D7_1116800; VEuPathDB:PF3D7_1116800
    Gene type
    protein coding
    RNA name
    heat shock protein 101
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1116800 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    4
    Sequence:
    Chromosome: 11; NC_037282.1 (636094..639511, complement)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, putative Neighboring gene dipeptidyl aminopeptidase 1 Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium membrane protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncoupling the Threading and Unfoldase Actions of Plasmodium HSP101 Reveals Differences in Export between Soluble and Insoluble Proteins. Matthews KM, et al. mBio, 2019 Jun 4. PMID 31164473, Free PMC Article
    2. The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface. Chisholm SA, et al. FEBS J, 2018 Jun. PMID 29637707
    3. PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes. Beck JR, et al. Nature, 2014 Jul 31. PMID 25043010, Free PMC Article
    4. A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell. Gabriela M, et al. PLoS Pathog, 2022 Feb. PMID 35192672, Free PMC Article
    5. Malaria parasite translocon structure and mechanism of effector export. Ho CM, et al. Nature, 2018 Sep. PMID 30150771, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein unfolding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within translocation of peptides or proteins into host cell cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of PTEX complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in merozoite dense granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in symbiont-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock protein 101

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      636094..639511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347810.1 → XP_001347846.1  heat shock protein 101 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001347846.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I0C0C9, Q8IIJ8, W4IRU9, W7JB37
      Conserved Domains (1) summary
      COG0542
      Location:36 → 893
      ClpA; ATP-dependent Clp protease ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6E11_1.1
    6E11_2.1
    6E11_3.1
    6E11_4.1
    6E11_5.1
    6E11_6.1

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