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    PF3D7_1147500 protein farnesyltransferase subunit beta [ Plasmodium falciparum 3D7 ]

    Gene ID: 811026, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1147500
    Gene description
    protein farnesyltransferase subunit beta
    Locus tag
    PF3D7_1147500
    See related
    PlasmoDB:PF3D7_1147500; VEuPathDB:PF3D7_1147500
    Gene type
    protein coding
    RNA name
    protein farnesyltransferase subunit beta
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1147500 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    1
    Sequence:
    Chromosome: 11; NC_037282.1 (1889826..1892597, complement)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ATP synthase subunit delta, mitochondrial, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. Eastman RT, et al. J Biol Chem, 2005 Apr 8. PMID 15661734
    2. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. Chakrabarti D, et al. J Biol Chem, 2002 Nov 1. PMID 12194969
    3. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Cowell AN, et al. Science, 2018 Jan 12. PMID 29326268, Free PMC Article
    4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein farnesylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein farnesyltransferase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    protein farnesyltransferase subunit beta
    XP_001348150.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      1889826..1892597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348114.2 → XP_001348150.2  protein farnesyltransferase subunit beta [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348150.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WIP2, Q5EI74, Q8IHP6, W7JRW6
      Conserved Domains (1) summary
      cd02893
      Location:425 → 848
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
    Nucleotide Protein
    Heading Accession and Version

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