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    PF3D7_1218300 AP-2 complex subunit mu, putative [ Plasmodium falciparum 3D7 ]

    Gene ID: 811229, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1218300
    Gene description
    AP-2 complex subunit mu, putative
    Locus tag
    PF3D7_1218300
    See related
    PlasmoDB:PF3D7_1218300; VEuPathDB:PF3D7_1218300
    Gene type
    protein coding
    RNA name
    AP-2 complex subunit mu, putative
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1218300 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    1
    Sequence:
    Chromosome: 12; NC_037284.1 (717955..719820)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene triose or hexose phosphate/phosphate translocator, putative Neighboring gene dynamin-like protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine. Henriques G, et al. Antimicrob Agents Chemother, 2015 May. PMID 25691625, Free PMC Article
    2. The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. Henrici RC, et al. mBio, 2020 Feb 25. PMID 32098816, Free PMC Article
    3. A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites. Birnbaum J, et al. Science, 2020 Jan 3. PMID 31896710
    4. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article
    5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    NOT enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within schizogony IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    AP-2 complex subunit mu, putative

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      717955..719820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350549.1 → XP_001350585.1  AP-2 complex subunit mu, putative [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350585.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WMP7, A0A024X6R7, Q8I5M5, W4J1E1, W7F508, W7JKB8, W7JRK9
      Conserved Domains (2) summary
      cl38905
      Location:1 → 131
      longin-like; Longin-like domains
      cl10970
      Location:255 → 620
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    Nucleotide Protein
    Heading Accession and Version

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