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    PF3D7_1251200 coronin [ Plasmodium falciparum 3D7 ]

    Gene ID: 811544, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1251200
    Gene description
    coronin
    Locus tag
    PF3D7_1251200
    See related
    PlasmoDB:PF3D7_1251200; VEuPathDB:PF3D7_1251200
    Gene type
    protein coding
    RNA name
    coronin
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1251200 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    3
    Sequence:
    Chromosome: 12; NC_037284.1 (2092087..2094231)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperone, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene thymidylate kinase Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility. Demas AR, et al. Proc Natl Acad Sci U S A, 2018 Dec 11. PMID 30420498, Free PMC Article
    2. The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites. Bane KS, et al. PLoS Pathog, 2016 Jul. PMID 27409081, Free PMC Article
    3. Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites. Olshina MA, et al. Malar J, 2015 Jul 18. PMID 26187846, Free PMC Article
    4. Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum. Sharma AI, et al. PLoS Genet, 2020 Dec. PMID 33370279, Free PMC Article
    5. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studied the N-terminal beta-propeller domain of PfCoronin and the binding of it to F-actin and the facilitation of formation of parallel filament bundles.
      Title: Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell motility ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in pellicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coronin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      2092087..2094231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350860.1 → XP_001350896.1  coronin [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350896.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024W2F4, A0A024X381, A0A0L7KHC6, A0A0L7LZY8, Q8I4S2, W4ICC9, W4J129, W7J7V9, W7JQH8
      Conserved Domains (2) summary
      PTZ00420
      Location:1 → 598
      PTZ00420; coronin; Provisional
      sd00039
      Location:78 → 123
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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