U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PF3D7_1303500 sodium/hydrogen exchanger [ Plasmodium falciparum 3D7 ]

    Gene ID: 813998, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PF3D7_1303500
    Gene description
    sodium/hydrogen exchanger
    Locus tag
    PF3D7_1303500
    See related
    PlasmoDB:PF3D7_1303500; VEuPathDB:PF3D7_1303500
    Gene type
    protein coding
    RNA name
    sodium/hydrogen exchanger
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PF3D7_1303500 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    2
    Sequence:
    Chromosome: 13; NC_004331.3 (169874..175789, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene LisH domain-containing protein, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene tetratricopeptide repeat protein, putative

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Polymorphism of Plasmodium falciparum Na(+)/H(+) exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam. Sinou V, et al. Malar J, 2011 Jun 14. PMID 21669011, Free PMC Article
    2. Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Nkrumah LJ, et al. Mol Biochem Parasitol, 2009 Jun. PMID 19428659, Free PMC Article
    3. Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance. Bennett TN, et al. Mol Biochem Parasitol, 2007 May. PMID 17353059, Free PMC Article
    4. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. Krogh A, et al. J Mol Biol, 2001 Jan 19. PMID 11152613
    5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. significant associations were found between polymorphisms at pfnhe1 (PF13_0019) microsatellite ms4760 and susceptibility to quinine
      Title: Polymorphism of Plasmodium falciparum Na(+)/H(+) exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sodium/hydrogen exchanger

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      169874..175789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349726.1 → XP_001349762.1  sodium/hydrogen exchanger [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349762.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WMB9, Q8IET0, W7K2E1
      Conserved Domains (1) summary
      cl01133
      Location:238 → 646
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials