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    PF3D7_1347200 nucleoside transporter 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 814217, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1347200
    Gene description
    nucleoside transporter 1
    Locus tag
    PF3D7_1347200
    See related
    PlasmoDB:PF3D7_1347200; VEuPathDB:PF3D7_1347200
    Gene type
    protein coding
    RNA name
    nucleoside transporter 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1347200 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Sequence:
    Chromosome: 13; NC_004331.3 (1889853..1891121, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein 92, putative Neighboring gene DNA topoisomerase 3, putative Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation. Sosa Y, et al. ACS Infect Dis, 2019 Oct 11. PMID 31373203, Free PMC Article
    2. Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Nishtala SN, et al. J Biol Chem, 2019 Feb 8. PMID 30541922, Free PMC Article
    3. Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites. Frame IJ, et al. ACS Chem Biol, 2015 Mar 20. PMID 25602169, Free PMC Article
    4. Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Riegelhaupt PM, et al. Mol Biochem Parasitol, 2010 Jan. PMID 19818813, Free PMC Article
    5. Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum. El Bissati K, et al. Mol Biochem Parasitol, 2008 Oct. PMID 18639591, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results may help identify the binding site(s) of PfENT1 inhibitors
      Title: Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
    2. ENT1 mediated transport of natural purine substrates.
      Title: Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
    3. Taken together these results demonstrate that, in addition to hypoxanthine, inosine and adenosine, PfNT1 is essential for the transport and utilization of xanthine, guanine and guanosine.
      Title: Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum.
    4. Data report that transgenic parasites lacking NT1 (nucleoside transporter 1) are auxotrophic for hypoxanthine, inosine, and adenosine under physiological conditions and are viable only if these nutrients are provided at excess concentrations.
      Title: The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.
    5. Serveing as a major route for the uptake of nucleosides across the parasite plasma membrane.
      Title: Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables purine nucleoside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within purine nucleoside transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoside transporter 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1889853..1891121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350150.1 → XP_001350186.1  nucleoside transporter 1 [Plasmodium falciparum 3D7]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IDM6
      UniProtKB/TrEMBL
      A0A024V3E5, A0A024VKK8, A0A0L1I854, A0A0L7LY11, Q9NIH7, Q9NIH8, W4IC46, W7F991, W7JI90, W7KAP3
      Conserved Domains (1) summary
      cl15430
      Location:104 → 357
      Nucleoside_tran; Nucleoside transporter
    Nucleotide Protein
    Heading Accession and Version

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