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    PF3D7_1462800 glyceraldehyde-3-phosphate dehydrogenase [ Plasmodium falciparum 3D7 ]

    Gene ID: 812180, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_1462800
    Gene description
    glyceraldehyde-3-phosphate dehydrogenase
    Primary source
    PlasmoDB:PF3D7_1462800
    Locus tag
    PF3D7_1462800
    See related
    VEuPathDB:PF3D7_1462800
    Gene type
    protein coding
    RNA name
    glyceraldehyde-3-phosphate dehydrogenase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_1462800 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    2
    Sequence:
    Chromosome: 14; NC_037283.1 (2559098..2560347)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene cytochrome c1 precursor, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene mediator of RNA polymerase II transcription subunit 20, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria. Bruno S, et al. J Med Chem, 2014 Sep 11. PMID 25137375
    2. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Robien MA, et al. Proteins, 2006 Mar 15. PMID 16345073
    3. Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum. Satchell JF, et al. Acta Crystallogr D Biol Crystallogr, 2005 Sep. PMID 16131754
    4. The N'-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes. Daubenberger CA, et al. Biol Chem, 2003 Aug. PMID 12974391
    5. Identification and recombinant expression of glyceraldehyde-3-phosphate dehydrogenase of Plasmodium falciparum. Daubenberger CA, et al. Gene, 2000 Apr 4. PMID 10767547

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the 3-bromo-isoxazoline derivatives showed a time- and concentration-dependent inactivatioof glyceraldehyde-3-phosphate dehydrogenase (GAPDH), with a large variability in reaction rates
      Title: Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria.
    2. The major structural feature distinguishing human GAPDH from PfGAPDH is the insertion of a dipeptide (-KG-) in the so-called S loop, which alters the chemical environment of the groove that encompasses the R dyad and links adjacent cofactor-binding sites
      Title: Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.
    3. In all four subunits a completely unexpected large island of extra electron density in the active site is observed.
      Title: Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gluconeogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within glycolytic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in food vacuole HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase
    XP_001348772.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      2559098..2560347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348736.3 → XP_001348772.1  glyceraldehyde-3-phosphate dehydrogenase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348772.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024V013, A0A024VYW4, A0A024WHA8, A0A024X0L3, A0A0L1IBY1, A0A0L7KDR6, A0A2I0C1J8, Q8IKK7, Q8T6B1, W4I9B4, W7F419, W7FMT1, W7J3S3
      Conserved Domains (1) summary
      PTZ00023
      Location:2 → 337
      PTZ00023; glyceraldehyde-3-phosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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