PF3D7_0304600 circumsporozoite (CS) protein [Plasmodium falciparum 3D7] - Gene

Summary

Go to the top of the page Help

Gene symbol: PF3D7_0304600
Gene description: circumsporozoite (CS) protein
Locus tag: PF3D7_0304600
See related: PlasmoDB:PF3D7_0304600; VEuPathDB:PF3D7_0304600
Gene type: protein coding
RNA name: circumsporozoite (CS) protein
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PF3D7_0304600 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_000521.4 (221323..222516, complement)

Chromosome 3 - NC_000521.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_000521.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic variations of Plasmodium falciparum circumsporozoite protein and the impact on interactions with human immunoproteins and malaria vaccine efficacy.
Title: Genetic variations of Plasmodium falciparum circumsporozoite protein and the impact on interactions with human immunoproteins and malaria vaccine efficacy.
Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes.
Title: Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes.
Live attenuated rubella vectors expressing Plasmodium falciparum circumsporozoite protein (Pf-CSP) provide a novel malaria vaccine platform in the rhesus macaque.
Title: Live attenuated rubella vectors expressing Plasmodium falciparum circumsporozoite protein (Pf-CSP) provide a novel malaria vaccine platform in the rhesus macaque.
The circumsporozoite protein (CSP) and the thrombospondin-related anonymous protein (TRAP) bind to the heparan sulfate proteoglycan on the hepatocyte surface and contribute to sporozoite infection and hepatocyte selectivity.
Title: Malaria sporozoite protein expression enhances baculovirus-mediated gene transfer to hepatocytes.
CSP is N-terminally processed in the mosquito host and undergoes a reversible conformational change to mask some epitopes in the N- and C-terminal domains until the sporozoite interacts with the liver hepatocyte.
Title: Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains.
An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.
Title: An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.
Data indicate that the self-assembling protein nanoparticle (SAPN) vaccine construct induces long-lasting antibody and cellular immune responses to epitope specific sequences of the circumsporozoite protein (PfCSP).
Title: Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine.
Data indicate that the circumsporozoite protein (PfCSP) in sporozoite (PfSPZ) was highly sensitive and reproducible measured by the assay.
Title: A chemiluminescent-western blot assay for quantitative detection of Plasmodium falciparum circumsporozoite protein.
results revealed that the central repeat (63 haplotypes) and C-terminal Th2R/Th3R epitope (24 haplotypes) regions were highly polymorphic.
Title: Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine.
Data show that native CSP appears as a glycosylphosphatidylinositol-anchored, flexible rod-like protein on the sporozoite surface.
Title: Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by GeneDB

Function	Evidence Code	Pubs
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables host cell surface binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within exit from host cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within symbiont entry into host	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in host cell cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in host cell nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed