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    PF3D7_0320900 histone H2A.Z [ Plasmodium falciparum 3D7 ]

    Gene ID: 814523, updated on 18-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0320900
    Gene description
    histone H2A.Z
    Locus tag
    PF3D7_0320900
    See related
    PlasmoDB:PF3D7_0320900; VEuPathDB:PF3D7_0320900
    Gene type
    protein coding
    RNA name
    histone H2A.Z
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0320900 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_000521.4 (875213..876295)

    Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 2 Neighboring gene ATP-dependent RNA helicase DDX6 Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000521.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences. Tang J, et al. Epigenetics Chromatin, 2020 Nov 23. PMID 33225957, Free PMC Article
    2. H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3. Bártfai R, et al. PLoS Pathog, 2010 Dec 16. PMID 21187892, Free PMC Article
    3. H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum. Petter M, et al. Mol Microbiol, 2013 Mar. PMID 23373537
    4. Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite. Sinha A, et al. mBio, 2021 Apr 27. PMID 33906926, Free PMC Article
    5. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature, 1999 Aug 5. PMID 10448855

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, Plasmodium falciparum H2A.Z/Pf H2B.Z double-variant nucleosomes appear to have a highly specific function in the regulation of virulence.
      Title: H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum.
    2. findings place H2A.Z at the cradle of P. falciparum epigenetic regulation by stably defining intergenic regions and providing a platform for dynamic assembly of epigenetic and other transcription related complexes.
      Title: H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    histone H2A.Z

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000521.4 Reference assembly

      Range
      875213..876295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351243.1 → XP_001351279.1  histone H2A.Z [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351279.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WDY3, A0A024WXI9, A0A024XDA7, A0A0L1IFB1, A0A2I0BTA7, O97320, W4IPR1, W7GCD1
      Conserved Domains (1) summary
      PTZ00017
      Location:39 → 157
      PTZ00017; histone H2A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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