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    PF3D7_0323400 Rh5 interacting protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 814549, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0323400
    Gene description
    Rh5 interacting protein
    Locus tag
    PF3D7_0323400
    See related
    PlasmoDB:PF3D7_0323400; VEuPathDB:PF3D7_0323400
    Gene type
    protein coding
    RNA name
    Rh5 interacting protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0323400 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_000521.4 (980706..983966, complement)

    Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene survival motor neuron-like protein Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000521.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A. Nagaoka H, et al. Sci Rep, 2020 Apr 20. PMID 32313230, Free PMC Article
    2. Identification of Plasmodium falciparum reticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine candidate. Ntege EH, et al. Vaccine, 2016 Nov 4. PMID 27692771
    3. An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum. Chen L, et al. PLoS Pathog, 2011 Sep. PMID 21909261, Free PMC Article
    4. Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion. Reddy KS, et al. Proc Natl Acad Sci U S A, 2015 Jan 27. PMID 25583518, Free PMC Article
    5. Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Wong W, et al. Nature, 2019 Jan. PMID 30542156

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables host cell surface binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein insertion into membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rh5 interacting protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000521.4 Reference assembly

      Range
      980706..983966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351269.1 → XP_001351305.1  Rh5 interacting protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351305.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O97302
      UniProtKB/TrEMBL
      A0A024VWJ5, A0A024WXT8, A0A024XED2, A0A0L1ID04, A0A193PDI4, A0A193PDI9, A0A193PDJ4, A0A193PDJ9, A0A193PDK3, A0A193PDK8, A0A193PDL3, A0A193PDL9, A0A193PDM4, A0A193PDN7, A0A193PDP4, A0A193PDQ4, A0A193PDQ8, A0A193PDR2, A0A193PDZ5, A0A193PDZ8, A0A193PE01, A0A193PE02, A0A193PE05, A0A193PE07, A0A193PE08, A0A193PE10, A0A193PE14, A0A193PE16, A0A193PE17, A0A193PE18, A0A193PE20, A0A193PE22, A0A193PE23, A0A193PE24, A0A193PE26, A0A193PE27, A0A193PE28, A0A193PE31, A0A193PE34, A0A193PE35, A0A193PE37, A0A193PE38, A0A193PE39, A0A193PE41, A0A193PE42, A0A193PE43, A0A193PE45, A0A193PE46, A0A193PE47, A0A193PE49, A0A193PE50, A0A193PE53, A0A193PE57, A0A193PE58, A0A193PE60, A0A193PE62, A0A193PE65, A0A193PE67, A0A193PE69, A0A193PE71, A0A193PEY6, A0A193PEZ1, A0A193PEZ6, A0A193PF01, A0A193PF06, A0A193PF11, A0A193PF21, A0A193PF26, A0A193PF31, A0A193PF36, A0A193PF41, A0A193PF51, W4IRK1, W7FWH4, W7JI43, W7KCI0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97302.1

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