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    PF3D7_0404700 dipeptidyl aminopeptidase 3 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812449, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0404700
    Gene description
    dipeptidyl aminopeptidase 3
    Locus tag
    PF3D7_0404700
    See related
    PlasmoDB:PF3D7_0404700; VEuPathDB:PF3D7_0404700
    Gene type
    protein coding
    RNA name
    dipeptidyl aminopeptidase 3
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0404700 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_004318.2 (260454..263418, complement)

    Chromosome 4 - NC_004318.2Genomic Context describing neighboring genes Neighboring gene 6-cysteine protein P52 Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene 6-cysteine protein P41

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004318.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite. Lehmann C, et al. PLoS Pathog, 2018 May. PMID 29768491, Free PMC Article
    2. The cysteine protease dipeptidyl aminopeptidase 3 does not contribute to egress of Plasmodium falciparum from host red blood cells. Ghosh S, et al. PLoS One, 2018. PMID 29509772, Free PMC Article
    3. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Hu G, et al. Nat Biotechnol, 2010 Jan. PMID 20037583
    4. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556
    5. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidyl aminopeptidase 3
    XP_001351359.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004318.2 Reference assembly

      Range
      260454..263418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351323.2 → XP_001351359.2  dipeptidyl aminopeptidase 3 [Plasmodium falciparum 3D7]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I0BZE3, A0A8S9VNR5, Q8I1Y2
      Conserved Domains (2) summary
      pfam08773
      Location:149 → 193
      CathepsinC_exc; Cathepsin C exclusion domain
      cl23744
      Location:471 → 929
      Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
    Nucleotide Protein
    Heading Accession and Version

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