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    PF3D7_0513300 purine nucleoside phosphorylase [ Plasmodium falciparum 3D7 ]

    Gene ID: 812947, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0513300
    Gene description
    purine nucleoside phosphorylase
    Locus tag
    PF3D7_0513300
    See related
    PlasmoDB:PF3D7_0513300; VEuPathDB:PF3D7_0513300
    Gene type
    protein coding
    RNA name
    purine nucleoside phosphorylase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0513300 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_004326.2 (569182..569919, complement)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene GTP-binding protein, putative Neighboring gene mitochondrial import inner membrane translocase subunit TIM16, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay. Dziekan JM, et al. Sci Transl Med, 2019 Jan 2. PMID 30602534
    2. Identification of a novel putative inhibitor of the Plasmodium falciparum purine nucleoside phosphorylase: exploring the purine salvage pathway to design new antimalarial drugs. Kagami LP, et al. Mol Divers, 2017 Aug. PMID 28523625
    3. Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. Shi W, et al. J Biol Chem, 2004 Apr 30. PMID 14982926
    4. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556
    5. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables purine-nucleoside phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleoside catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    purine nucleoside phosphorylase
    XP_001351690.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      569182..569919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351654.1 → XP_001351690.1  purine nucleoside phosphorylase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351690.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I3X4, Q8T9Z7
      UniProtKB/TrEMBL
      A0A024VCE7, A0A024VTV3, A0A024WUP1, A0A024XBX4, A0A0L1I561, A0A0L7K5U1, A0A0L7M7R1, W4ILI6, W4IVZ2, W7F6C4, W7GAS3, W7JSY1, W7KKX8
      Conserved Domains (1) summary
      cd17767
      Location:7 → 238
      UP_EcUdp-like; uridine phosphorylases similar to Escherichia coli Udp and related phosphorylases
    Nucleotide Protein
    Heading Accession and Version

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