Rgs9 regulator of G-protein signaling 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs9provided by RGD
Official Full Name: regulator of G-protein signaling 9provided by RGD
Primary source: RGD:3572
See related: EnsemblRapid:ENSRNOG00000003800 AllianceGenome:RGD:3572
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase activator activity. Involved in several processes, including G protein-coupled dopamine receptor signaling pathway; regulation of monoatomic ion transmembrane transport; and response to estradiol. Predicted to be located in membrane. Predicted to be active in several cellular components, including glutamatergic synapse; neuron projection; and synaptic membrane. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 77.9), Uterus (RPKM 17.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (94696556..94770387, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (94195265..94270892, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (97509971..97582188, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight.
Title: Association between regulator of G protein signaling 9-2 and body weight.
RGS9 expression in striatum may involve in the abnormal involuntary movements induced by l-DOPA therapy
Title: The involvement of RGS9 in l-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model.
This study demonstrates that ontogenetic quinpirole treatment, which results in priming of the D(2) receptor, results in significant decreases in Rgs9, which has been shown to regulate G-protein coupling to D(2) receptors.
Title: Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex.
Evidence for the involvement of ERbeta and RGS9-2 in 17-beta estradiol enhancement of amphetamine-induced place preference behavior.
Title: Evidence for the involvement of ERbeta and RGS9-2 in 17-beta estradiol enhancement of amphetamine-induced place preference behavior.
specific regulator of dopamine receptor-mediated signaling in the striatum
Title: RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons.
These data suggest that RGS9 is differentially expressed with age. Such differential expression may play an important role in neuronal differentiation and development as well as in neuronal function, such as dopamine and opioid signaling.
Title: Differential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats.
opiate-induced changes in RGS9 levels contribute to the behavioral and neural plasticity associated with chronic opiate administration
Title: Essential role for RGS9 in opiate action.
The nuclear localization of RGS9-2 suggests a heretofore-unanticipated role for this brain-specific protein in transducing signals to the nuclei of forebrain neurons.
Title: Brain-specific RGS9-2 is localized to the nucleus via its unique proline-rich domain.
data demonstrate a functional interaction between RGS9-2 and D2 receptor signaling and the behavioral actions of psychostimulants and suggest that psychostimulant induction of RGS9-2 represents a compensatory adaptation that diminishes drug responsiveness
Title: RGS9 modulates dopamine signaling in the basal ganglia.

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General gene information

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Markers

RH139432 (e-PCR)
- UniSTS:221518

BE119038 (e-PCR)
- UniSTS:249075

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dark adaptation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within light adaption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulator of G-protein signaling 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019224.2 → NP_062097.1 regulator of G-protein signaling 9

See identical proteins and their annotated locations for NP_062097.1

Status: PROVISIONAL

Source sequence(s)

AB019145

UniProtKB/Swiss-Prot

P49805

UniProtKB/TrEMBL

A0A8I5ZNC0, A6HKA1

Related

ENSRNOP00000005076.7, ENSRNOT00000005076.8

Conserved Domains (3) summary

smart00224
Location:219 → 280

GGL; G protein gamma subunit-like motifs

cd08739
Location:292 → 412

RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein

cd04450
Location:22 → 109

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...