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    Tango2 transport and golgi organization 2 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360738, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tango2provided by RGD
    Official Full Name
    transport and golgi organization 2 homologprovided by RGD
    Primary source
    RGD:1310348
    See related
    EnsemblRapid:ENSRNOG00000030245 AllianceGenome:RGD:1310348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310348
    Summary
    Predicted to be involved in Golgi organization and protein secretion. Predicted to be located in cytosol and mitochondrion. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in TANGO2-related metabolic encephalopathy and arrythmias. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 231.3), Brain (RPKM 109.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tango2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96150292..96196883)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82645978..82692574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86793959..86840556)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene thioredoxin reductase 2 Neighboring gene catechol-O-methyltransferase Neighboring gene ARVCF, delta catenin family member Neighboring gene small Cajal body-specific RNA 14 like 2 Neighboring gene microRNA 185 Neighboring gene AP-3 complex subunit sigma-1-like Neighboring gene microRNA 1306 Neighboring gene DGCR8 microprocessor complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. Lalani SR, et al. Am J Hum Genet, 2016 Feb 4. PMID 26805781, Free PMC Article
    2. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108323.1 → NP_001101793.1  transport and Golgi organization protein 2 homolog

      See identical proteins and their annotated locations for NP_001101793.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A6JSH0, A6JSH4, D3ZY86
      Related
      ENSRNOP00000044441.3, ENSRNOT00000046594.7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organization 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96150292..96196883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088516.2 → XP_038944444.1  transport and Golgi organization protein 2 homolog isoform X11

      UniProtKB/TrEMBL
      A6JSH4
      Conserved Domains (1) summary
      pfam05742
      Location:2 → 243
      TANGO2; Transport and Golgi organisation 2

    2. XM_039088504.2 → XP_038944432.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 294
      TANGO2; Transport and Golgi organisation 2

    3. XM_039088503.2 → XP_038944431.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 294
      TANGO2; Transport and Golgi organisation 2

    4. XM_063270650.1 → XP_063126720.1  transport and Golgi organization protein 2 homolog isoform X5

    5. XM_063270654.1 → XP_063126724.1  transport and Golgi organization protein 2 homolog isoform X13

    6. XM_017598030.3 → XP_017453519.1  transport and Golgi organization protein 2 homolog isoform X8

      UniProtKB/TrEMBL
      A0A8I6G5G3, A6JSG9, A6JSH2
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 237
      TANGO2; Transport and Golgi organization 2

    7. XM_039088510.2 → XP_038944438.1  transport and Golgi organization protein 2 homolog isoform X6

      UniProtKB/TrEMBL
      A0A0G2JXP4
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    8. XM_063270657.1 → XP_063126727.1  transport and Golgi organization protein 2 homolog isoform X16

    9. XM_039088522.2 → XP_038944450.1  transport and Golgi organization protein 2 homolog isoform X17

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 152
      TANGO2; Transport and Golgi organisation 2

    10. XM_017598033.3 → XP_017453522.1  transport and Golgi organization protein 2 homolog isoform X9

      UniProtKB/TrEMBL
      A6JSH0, A6JSH4, D3ZY86
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organization 2

    11. XM_039088502.2 → XP_038944430.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 294
      TANGO2; Transport and Golgi organisation 2

    12. XM_039088507.2 → XP_038944435.1  transport and Golgi organization protein 2 homolog isoform X3

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 272
      TANGO2; Transport and Golgi organisation 2

    13. XM_039088515.2 → XP_038944443.1  transport and Golgi organization protein 2 homolog isoform X10

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    14. XM_039088514.2 → XP_038944442.1  transport and Golgi organization protein 2 homolog isoform X7

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    15. XM_039088506.2 → XP_038944434.1  transport and Golgi organization protein 2 homolog isoform X2

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 291
      TANGO2; Transport and Golgi organisation 2

    16. XM_039088508.2 → XP_038944436.1  transport and Golgi organization protein 2 homolog isoform X4

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 294
      TANGO2; Transport and Golgi organisation 2

    17. XM_039088509.2 → XP_038944437.1  transport and Golgi organization protein 2 homolog isoform X6

      UniProtKB/TrEMBL
      A0A0G2JXP4
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    18. XM_017598031.3 → XP_017453520.1  transport and Golgi organization protein 2 homolog isoform X8

      UniProtKB/TrEMBL
      A0A8I6G5G3, A6JSG9, A6JSH2
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 237
      TANGO2; Transport and Golgi organization 2

    19. XM_063270655.1 → XP_063126725.1  transport and Golgi organization protein 2 homolog isoform X13

    20. XM_039088517.2 → XP_038944445.1  transport and Golgi organization protein 2 homolog isoform X12

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 224
      TANGO2; Transport and Golgi organisation 2

    21. XM_039088520.2 → XP_038944448.1  transport and Golgi organization protein 2 homolog isoform X16

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 151
      TANGO2; Transport and Golgi organisation 2

    22. XM_039088521.2 → XP_038944449.1  transport and Golgi organization protein 2 homolog isoform X17

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 152
      TANGO2; Transport and Golgi organisation 2

    23. XM_039088518.2 → XP_038944446.1  transport and Golgi organization protein 2 homolog isoform X14

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 151
      TANGO2; Transport and Golgi organisation 2

    24. XM_039088519.2 → XP_038944447.1  transport and Golgi organization protein 2 homolog isoform X15

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 160
      TANGO2; Transport and Golgi organisation 2

    25. XM_039088523.2 → XP_038944451.1  transport and Golgi organization protein 2 homolog isoform X18

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 151
      TANGO2; Transport and Golgi organisation 2

    26. XM_063270652.1 → XP_063126722.1  transport and Golgi organization protein 2 homolog isoform X9

      UniProtKB/TrEMBL
      A6JSH0, D3ZY86

    27. XM_039088505.2 → XP_038944433.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1 → 294
      TANGO2; Transport and Golgi organisation 2

    28. XM_063270656.1 → XP_063126726.1  transport and Golgi organization protein 2 homolog isoform X13

    29. XM_063270651.1 → XP_063126721.1  transport and Golgi organization protein 2 homolog isoform X8

      UniProtKB/TrEMBL
      A0A8I6G5G3, A6JSG9

    30. XM_039088513.2 → XP_038944441.1  transport and Golgi organization protein 2 homolog isoform X6

      UniProtKB/TrEMBL
      A0A0G2JXP4
      Related
      ENSRNOP00000081064.2, ENSRNOT00000103259.2
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    RNA

    1. XR_005491043.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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