DUSP19 dual specificity phosphatase 19 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP19provided by HGNC
Official Full Name: dual specificity phosphatase 19provided by HGNC
Primary source: HGNC:HGNC:18894
See related: Ensembl:ENSG00000162999 MIM:611437; AllianceGenome:HGNC:18894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SKRP1; DUSP17; LMWDSP3; TS-DSP1
Summary: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 2q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (183078747..183100008)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (183567739..183589000)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (183943475..183964736)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
Title: PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.
Title: Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.
DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
Title: DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression.
Title: DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.
crystal structure of SKRP1 (C150S) has been determined and refined at 1.26 A resolution (Table I). The structure reveals 142 residues (residues 65-206) of SKRP1 and three ions (two sulfates and one phosphate) at the catalytic site
Title: Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1.
LMW-DSP3 was expressed in the heart, lung, liver, and pancreas, and the expression level in the pancreas was highest. The LMW-DSP3 gene was located in human chromosome 2q32, and consisted of five exons spanning 21kb of human genomic DNA[LMW-DSP3]
Title: Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S275 (e-PCR)
- UniSTS:147992

RH92337 (e-PCR)
- UniSTS:84007

PMC156606P1 (e-PCR)
- UniSTS:271408

NoName (e-PCR)
- UniSTS:483680

L17709 (e-PCR)
- UniSTS:42599

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables JUN kinase phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase kinase kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase 19

Names: SAPK pathway-regulating phosphatase 1; dual specificity phosphatase TS-DSP1; low molecular weight dual specificity phosphatase 3; protein phosphatase SKRP1; stress-activated protein kinase pathway-regulating phosphatase 1

NP_001135786.1

EC 3.1.3.16

EC 3.1.3.48

NP_001308448.1

EC 3.1.3.16

EC 3.1.3.48

NP_543152.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142314.2 → NP_001135786.1 dual specificity protein phosphatase 19 isoform 2

See identical proteins and their annotated locations for NP_001135786.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AB063187, AC064871, BC035000

Consensus CDS

CCDS46469.1

UniProtKB/Swiss-Prot

Q8WTR2

Related

ENSP00000343905.6, ENST00000342619.10

Conserved Domains (1) summary

cl28904
Location:65 → 150

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001321519.2 → NP_001308448.1 dual specificity protein phosphatase 19 isoform 3

Status: VALIDATED

Source sequence(s)

AB063186, AC064871, BX647818

UniProtKB/Swiss-Prot

Q8WTR2

Conserved Domains (1) summary

cl28904
Location:65 → 96

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_080876.4 → NP_543152.1 dual specificity protein phosphatase 19 isoform 1

See identical proteins and their annotated locations for NP_543152.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB063186, AC064871, BC035000

Consensus CDS

CCDS2289.1

UniProtKB/Swiss-Prot

B2RA79, Q547H4, Q8WTR2, Q8WYN4

Related

ENSP00000346160.4, ENST00000354221.5

Conserved Domains (1) summary

cd14523
Location:65 → 201

DSP_DUSP19; dual specificity phosphatase domain of dual specificity protein phosphatase 19