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    Insig1 insulin induced gene 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64194, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Insig1provided by RGD
    Official Full Name
    insulin induced gene 1provided by RGD
    Primary source
    RGD:708457
    See related
    EnsemblRapid:ENSRNOG00000006859 AllianceGenome:RGD:708457
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxysterol binding activity and protein sequestering activity. Involved in cellular response to insulin stimulus; response to estradiol; and response to fatty acid. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Biomarker of steatotic liver disease. Orthologous to human INSIG1 (insulin induced gene 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1052.8), Adrenal (RPKM 412.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Insig1 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (8049339..8057812, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (7315494..7323972, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (342302..350515)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene engrailed homeobox 2 Neighboring gene uncharacterized LOC134486707 Neighboring gene uncharacterized LOC102546740 Neighboring gene uncharacterized LOC103692012 Neighboring gene uncharacterized LOC134486708 Neighboring gene 5-hydroxytryptamine receptor 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c. Chen K, et al. J Biomed Sci, 2011 Aug 16. PMID 21843373, Free PMC Article
    2. Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells. Palaniappan M, et al. Biol Reprod, 2009 Aug. PMID 19299314, Free PMC Article
    3. Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. Bonzón-Kulichenko E, et al. Endocrinology, 2009 Jan. PMID 18801905
    4. Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats. Takaishi K, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15096598, Free PMC Article
    5. Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue. Boden G, et al. Obesity (Silver Spring), 2013 Jun. PMID 23913732, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest expression of hepatocyte Insig1/Insig2a and Crebh/Creb3l3 (cAMP responsive element-binding protein 3-like 3 protein) can be up-regulated by dietary factors (here, dietary supplementation with hypotriglyceridemic R-alpha-lipoic acid).
      Title: Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.
    2. INSIG-1 is decreased by insulin in liver and increased in fat.
      Title: Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue.
    3. Overexpression of Insig-1 protects beta cells against glucolipotoxicity via SREBP-1c.
      Title: Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxysterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SREBP-SCAP complex retention in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP-SCAP complex retention in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to sterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cranial suture morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within middle ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cargo loading into COPII-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sterol depletion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SREBP-SCAP-Insig complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SREBP-SCAP-Insig complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    insulin-induced gene 1 protein
    Names
    INSIG-1
    growth response protein (CL-6)
    immediate-early protein CL-6
    insulin-induced growth response protein CL-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022392.2 → NP_071787.1  insulin-induced gene 1 protein

      See identical proteins and their annotated locations for NP_071787.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q08755
      UniProtKB/TrEMBL
      A6KJL1
      Related
      ENSRNOP00000009233.4, ENSRNOT00000009233.8
      Conserved Domains (1) summary
      pfam07281
      Location:69 → 249
      INSIG; Insulin-induced protein (INSIG)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      8049339..8057812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108310.2 → XP_038964238.1  insulin-induced gene 1 protein isoform X3

      Conserved Domains (1) summary
      pfam07281
      Location:70 → 157
      INSIG; Insulin-induced protein (INSIG)

    2. XM_039108311.2 → XP_038964239.1  insulin-induced gene 1 protein isoform X4

      Conserved Domains (1) summary
      pfam07281
      Location:1 → 103
      INSIG; Insulin-induced protein (INSIG)

    3. XM_063286658.1 → XP_063142728.1  insulin-induced gene 1 protein isoform X1

    4. XM_063286659.1 → XP_063142729.1  insulin-induced gene 1 protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08755.1 GenPept UniProtKB/Swiss-Prot:Q08755

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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