Catsper2 cation channel, sperm associated 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Catsper2provided by RGD
Official Full Name: cation channel, sperm associated 2provided by RGD
Primary source: RGD:1307620
See related: EnsemblRapid:ENSRNOG00000023064 AllianceGenome:RGD:1307620
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in several processes, including calcium ion transport; flagellated sperm motility; and sperm capacitation. Predicted to be located in sperm flagellum. Predicted to be part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 133.8), Kidney (RPKM 16.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128822387..128842501, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (108368654..108389380, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (113357361..113379498, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
Title: The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
It is feasible to achieve male contraception by silencing the expression of CatSper2, the key protein involved in sperm hyperactivation.
Title: Regulation of fertilization in male rats by CatSper2 knockdown.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in fertilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CatSper complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CatSper complex	IEA Inferred from Electronic Annotation more info
part_of CatSper complex	ISO Inferred from Sequence Orthology more info
part_of CatSper complex	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cation channel sperm-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012220.1 → NP_001012220.1 cation channel sperm-associated protein 2

See identical proteins and their annotated locations for NP_001012220.1

Status: PROVISIONAL

Source sequence(s)

BC079422

UniProtKB/Swiss-Prot

Q6AXP6

UniProtKB/TrEMBL

A0A8I5ZML1, A6HPN9

Related

ENSRNOP00000038712.3, ENSRNOT00000030019.5

Conserved Domains (2) summary

pfam00183
Location:419 → 463

HSP90; Hsp90 protein

pfam00520
Location:138 → 348

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

128822387..128842501 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591949.3 → XP_017447438.1 cation channel sperm-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

Q6AXP6

UniProtKB/TrEMBL

A0A8I5ZML1, A6HPN9

Conserved Domains (2) summary

pfam00183
Location:419 → 463

HSP90; Hsp90 protein

pfam00520
Location:138 → 348

Ion_trans; Ion transport protein
XM_063284284.1 → XP_063140354.1 cation channel sperm-associated protein 2 isoform X2

Related

ENSRNOP00000098911.1, ENSRNOT00000136426.1
XM_008762187.4 → XP_008760409.1 cation channel sperm-associated protein 2 isoform X1

See identical proteins and their annotated locations for XP_008760409.1

UniProtKB/Swiss-Prot

Q6AXP6

UniProtKB/TrEMBL

A0A8I5ZML1, A6HPN9

Conserved Domains (2) summary

pfam00183
Location:419 → 463

HSP90; Hsp90 protein

pfam00520
Location:138 → 348

Ion_trans; Ion transport protein
XM_006234860.4 → XP_006234922.1 cation channel sperm-associated protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZML1

Conserved Domains (2) summary

pfam00183
Location:379 → 423

HSP90; Hsp90 protein

pfam00520
Location:146 → 308

Ion_trans; Ion transport protein