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    Crabp2 cellular retinoic acid binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29563, updated on 2-Nov-2024

    Summary

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    Symbol
    Crabp2provided by RGD
    Full Name
    cellular retinoic acid binding protein 2provided by RGD
    Primary source
    RGD:62070
    See related
    AllianceGenome:RGD:62070
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables retinoic acid binding activity. Involved in retinoic acid biosynthetic process. Predicted to be located in endoplasmic reticulum and nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 95.9), Thymus (RPKM 65.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crabp2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175714862..175719208)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173417004..173421352)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187322416..187326794)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene nestin Neighboring gene brevican

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus. Li XH, et al. J Biol Chem, 2003 Sep 12. PMID 12842898
    2. Inducible expression of cellular retinoic acid-binding protein II in rat ovary: gonadotropin regulation during luteal development. Bucco RA, et al. Endocrinology, 1995 Jun. PMID 7750498
    3. A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. Sessler RJ, et al. Mol Cell, 2005 Apr 29. PMID 15866176
    4. Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium. Asson-Batres MA, et al. Cell Tissue Res, 2003 Apr. PMID 12684871
    5. Affinity purification of retinoic acid-binding proteins using immobilized 4-(2-hydroxyethoxy)retinoic acid. Chapman JM, et al. Protein Expr Purif, 1990 Sep. PMID 1967079

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both CRABP II and CRABP I proteins and the mRNAs that encode them are present in postnatal rat olfactory epithelium; CRABP type II immunoreactivity was not observed in the mature rat retina
      Title: Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium.
    2. Gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus.
      Title: Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinoic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in retinoic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cellular retinoic acid-binding protein 2
    Names
    CRABP-II
    cellular lipid-binding protein
    cellular retinoic acid-binding protein 2-like
    cellular retinoic acid-binding protein II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017244.2 → NP_058940.1  cellular retinoic acid-binding protein 2

      See identical proteins and their annotated locations for NP_058940.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P51673
      UniProtKB/TrEMBL
      A0A8L2Q848
      Conserved Domains (1) summary
      cl10502
      Location:3 → 139
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175714862..175719208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51673.2 GenPept UniProtKB/Swiss-Prot:P51673

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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