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    Pecr peroxisomal trans-2-enoyl-CoA reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113956, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pecrprovided by RGD
    Official Full Name
    peroxisomal trans-2-enoyl-CoA reductaseprovided by RGD
    Primary source
    RGD:70925
    See related
    EnsemblRapid:ENSRNOG00000055295 AllianceGenome:RGD:70925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TERP
    Summary
    Predicted to enable signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in phytol metabolic process. Located in peroxisome. Orthologous to human PECR (peroxisomal trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1772.4), Kidney (RPKM 566.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pecr in Genome Data Viewer
    Location:
    9q33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (81347170..81375809, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (73897877..73926511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (79601937..79630547, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene voltage-dependent anion channel 2, pseudogene 1 Neighboring gene transmembrane protein 169 Neighboring gene X-ray repair cross complementing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a new fasting-inducible short-chain dehydrogenase/reductase from rat liver(1). Zhang J, et al. Biochim Biophys Acta, 1999 Nov 16. PMID 10561551
    2. Characterisation of several Hsp70 interacting proteins from mammalian organelles. Naylor DJ, et al. Biochim Biophys Acta, 1999 May 18. PMID 10350619
    3. Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation. Gloerich J, et al. FEBS Lett, 2006 Apr 3. PMID 16546181
    4. Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption. Satoh M, et al. Pancreas, 2013 Apr. PMID 23486364
    5. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that 2,4-dienoyl-CoA reductase and hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in alcohol-fed rats.
      Title: Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phytol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phytol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phytol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal trans-2-enoyl-CoA reductase
    Names
    PX-2,4-DCR1
    RLF98
    perosisomal 2-enoyl-CoA reductase
    peroxisomal 2,4-dienoyl-CoA reductase
    NP_579833.1
    XP_063122601.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133299.2 → NP_579833.1  peroxisomal trans-2-enoyl-CoA reductase

      See identical proteins and their annotated locations for NP_579833.1

      Status: PROVISIONAL

      Source sequence(s)
      AF021854
      UniProtKB/Swiss-Prot
      Q9WVK3
      UniProtKB/TrEMBL
      A0A8I6ATH4, A6KFH7
      Related
      ENSRNOP00000073815.2, ENSRNOT00000089283.3
      Conserved Domains (2) summary
      cd05369
      Location:16 → 267
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK05653
      Location:15 → 267
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      81347170..81375809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266531.1 → XP_063122601.1  peroxisomal trans-2-enoyl-CoA reductase isoform X1

      Related
      ENSRNOP00000069075.2, ENSRNOT00000086044.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVK3.1 GenPept UniProtKB/Swiss-Prot:Q9WVK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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