RSU1 Ras suppressor protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RSU1provided by HGNC
Official Full Name: Ras suppressor protein 1provided by HGNC
Primary source: HGNC:HGNC:10464
See related: Ensembl:ENSG00000148484 MIM:179555; AllianceGenome:HGNC:10464
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RSP-1
Summary: This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (16590611..16817424, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (16609081..16835881, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (16632610..16859423, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.
Title: CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.
Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.
Title: Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.
Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.
Title: Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.
Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.
Title: Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.
Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
Title: Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling.
Title: RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling.
Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
Title: Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
Title: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform.
Title: Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
CUBN is a gene locus for albuminuria. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N32556 (e-PCR)
- UniSTS:2089

D8S2279 (e-PCR)
- UniSTS:473907

WI-20644 (e-PCR)
- UniSTS:58458

STS-AA019537 (e-PCR)
- UniSTS:4958

A008Q44 (e-PCR)
- UniSTS:3935

RH36905 (e-PCR)
- UniSTS:87932

RH17616 (e-PCR)
- UniSTS:84361

SHGC-142403 (e-PCR)
- UniSTS:171439

RH103137 (e-PCR)
- UniSTS:97471

STS-AA012883 (e-PCR)
- UniSTS:79040

D10S1476 (e-PCR)
- UniSTS:70098

RH120632 (e-PCR)
- UniSTS:132573

D10S1661 (e-PCR), detects polymorphism
- UniSTS:9696

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras suppressor protein 1

Names: rsu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012425.4 → NP_036557.1 ras suppressor protein 1 isoform 1

See identical proteins and their annotated locations for NP_036557.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC073367, AK055596, BC005993, BG400752, BX647733

Consensus CDS

CCDS7112.1

UniProtKB/Swiss-Prot

A8KA46, D3DRU3, Q15404, Q6FI17

UniProtKB/TrEMBL

Q32Q10

Related

ENSP00000339521.5, ENST00000345264.10

Conserved Domains (2) summary

PLN00113
Location:34 → 200

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:19 → 41

LRR_RI; leucine-rich repeat [structural motif]
NM_152724.3 → NP_689937.2 ras suppressor protein 1 isoform 2

See identical proteins and their annotated locations for NP_689937.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been experimentally confirmed.

Source sequence(s)

AC073367, AK055596, BG400752, BX647733

Consensus CDS

CCDS31157.1

UniProtKB/TrEMBL

Q32Q10

Related

ENSP00000473588.1, ENST00000602389.1

Conserved Domains (3) summary

cd00116
Location:27 → 140

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:12 → 34

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:34 → 93

LRR_8; Leucine rich repeat