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    Duxbl1 double homeobox B-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 278672, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Duxbl1provided by MGI
    Official Full Name
    double homeobox B-like 1provided by MGI
    Primary source
    MGI:MGI:1916048
    See related
    Ensembl:ENSMUSG00000048502 AllianceGenome:MGI:1916048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Duxl; Duxbl; Duxbl2; Duxbl3; Gm10391; Gm10394; 1110051B16Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of T cell differentiation. Located in nucleus. Is expressed in several structures, including brain; early conceptus; and genitourinary system. Orthologous to human DUXB (double homeobox B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 4.8), CNS E14 (RPKM 2.8) and 9 other tissues See more
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    Genomic context

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    See Duxbl1 in Genome Data Viewer
    Location:
    14 A3; 14 15.3 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (25979011..25990590)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (25978560..25990166)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene cytoplasmic polyadenylated homeobox 1 Neighboring gene ubiquitin specific peptidase 7 pseudogene Neighboring gene predicted gene, 46445 Neighboring gene predicted gene, 34059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development. Kawazu M, et al. J Immunol, 2007 Oct 15. PMID 17911620
    2. Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl. Wu SL, et al. Dev Dyn, 2010 Mar. PMID 20063414
    3. The homeobox transcription factor DUXBL controls exit from totipotency. Vega-Sendino M, et al. Nat Genet, 2024 Apr. PMID 38509386, Free PMC Article
    4. The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection. Klein F, et al. J Exp Med, 2019 Mar 4. PMID 30765463, Free PMC Article
    5. DUX is a non-essential synchronizer of zygotic genome activation. De Iaco A, et al. Development, 2020 Jan 23. PMID 31806660, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Duxbl is a regulator of beta-selection by inducing apoptosis in T cells with a nonfunctional rearrangement.
      Title: The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.
    2. Duxbl proteins play regulatory roles during myogenesis and reproductive developments
      Title: Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.
    3. Involved in thymocyte development. Knockdown by shRNA impaired CD4/8 double-negative thymocyte differentiation. Overexpression impaired TCR-beta expression and CD4/8 double-positive thymocyte production. Expressed also in B-lymphocytes.
      Title: Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC67567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    double homeobox B-like 1
    Names
    Dux in lymphoid lineage
    doubl homeobox B-like 2
    double homeobox B-like 2
    double homeobox B-like 3
    double homeodomain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183389.2 → NP_899245.1  double homeobox B-like 1

      See identical proteins and their annotated locations for NP_899245.1

      Status: VALIDATED

      Source sequence(s)
      AK141686, BC055782
      Consensus CDS
      CCDS26878.1
      UniProtKB/TrEMBL
      Q7TNE6
      Related
      ENSMUSP00000056056.9, ENSMUST00000049793.9
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      25979011..25990590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158654.1 → XP_036014547.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_030247552.2 → XP_030103412.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    3. XM_036158649.1 → XP_036014542.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    4. XM_036158652.1 → XP_036014545.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    5. XM_011245082.2 → XP_011243384.1  double homeobox B-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011243384.1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    6. XM_036158646.1 → XP_036014539.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    7. XM_036158648.1 → XP_036014541.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    8. XM_030247843.1 → XP_030103703.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    9. XM_011245083.1 → XP_011243385.1  double homeobox B-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011243385.1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    10. XM_036158650.1 → XP_036014543.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    11. XM_036158651.1 → XP_036014544.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    12. XM_036158653.1 → XP_036014546.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    13. XM_030247844.1 → XP_030103704.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    14. XM_030247845.1 → XP_030103705.1  double homeobox B-like 1 isoform X1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    15. XM_006519079.1 → XP_006519142.1  double homeobox B-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006519142.1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    16. XM_006519077.4 → XP_006519140.1  double homeobox B-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006519140.1

      UniProtKB/TrEMBL
      Q7TNE6
      Conserved Domains (2) summary
      smart00389
      Location:95 → 149
      HOX; Homeodomain
      cd00086
      Location:15 → 71
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177538.2: Suppressed sequence

      Description
      NM_001177538.2: This RefSeq was removed because it is redundant with NM_183389.2.

    2. NM_001177539.2: Suppressed sequence

      Description
      NM_001177539.2: This RefSeq was removed because it is redundant with NM_183389.2.
    Nucleotide Protein Strain
    Heading Accession and Version

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