PRSS3 serine protease 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRSS3provided by HGNC
Official Full Name: serine protease 3provided by HGNC
Primary source: HGNC:HGNC:9486
See related: Ensembl:ENSG00000010438 MIM:613578; AllianceGenome:HGNC:9486
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T9; MTG; TRY3; TRY4; PRSS4
Summary: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Expression: Restricted expression toward pancreas (RPKM 3091.3) See more
Orthologs: all
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Genomic context

Location:: 9p13.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (33750679..33799231)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (33769262..33817820)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (33750677..33799229)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells.
Title: Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells.
Serine Protease 3 Promotes Progression of Diffuse Large B-Cell Lymphoma and Serves as a Novel Prognostic Predictor.
Title: Serine Protease 3 Promotes Progression of Diffuse Large B-Cell Lymphoma and Serves as a Novel Prognostic Predictor.
Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication.
Title: Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication.
In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer.
Title: In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer.
High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma.
Title: High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma.
Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
Title: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.
Title: Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Title: PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
PRSS contributes to cetuximab resistance in colorectal cancer.
Title: PRSS contributes to cetuximab resistance in colorectal cancer.
Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression
Title: Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-58840 (e-PCR)
- UniSTS:94467

G65748 (e-PCR)
- UniSTS:166708

NoName (e-PCR)
- UniSTS:480631

STS-X15505 (e-PCR)
- UniSTS:74448

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral response	TAS Traceable Author Statement more info
involved_in digestion	TAS Traceable Author Statement more info	PubMed
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in zymogen activation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in tertiary granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: trypsin-3

Names: brain trypsinogen; mesotrypsin; mesotrypsinogen; pancreatic trypsinogen III; protease, serine 3; protease, serine, 4 (trypsin 4, brain); trypsin III; trypsin IV; trypsinogen 4; trypsinogen 5; trypsinogen IV

NP_001184026.3

EC 3.4.21.4

NP_001184027.1

EC 3.4.21.4

NP_002762.3

EC 3.4.21.4

NP_031369.3

EC 3.4.21.4

XP_011516267.2

EC 3.4.21.4

XP_047279558.1

EC 3.4.21.4

XP_054219277.1

EC 3.4.21.4

XP_054219278.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_001337.2

Range

144006..192771

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GenBank, FASTA, Sequence Viewer (Graphics)
NG_029635.2 RefSeqGene

Range

49884..53554

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001197097.3 → NP_001184026.3 trypsin-3 isoform 3 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AL139113, AL356489, AL358573

UniProtKB/TrEMBL

A0A7P0MNE9

Related

ENSP00000340889.5, ENST00000342836.9

Conserved Domains (1) summary

cd00190
Location:38 → 256

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001197098.1 → NP_001184027.1 trypsin-3 isoform 4 preproprotein

See identical proteins and their annotated locations for NP_001184027.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a different in-frame first exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB298286

Consensus CDS

CCDS56570.1

UniProtKB/TrEMBL

Q8N2U3

Related

ENSP00000401828.3, ENST00000429677.8

Conserved Domains (2) summary

smart00020
Location:16 → 232

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:17 → 235

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_002771.4 → NP_002762.3 trypsin-3 isoform 2 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL139113, AL358573

Consensus CDS

CCDS6545.1

UniProtKB/TrEMBL

A1A508

Related

ENSP00000368715.3, ENST00000379405.4

Conserved Domains (1) summary

cd00190
Location:24 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_007343.4 → NP_031369.3 trypsin-3 isoform 1 preproprotein

Status: REVIEWED

Source sequence(s)

AL139113, AL356489, AL358573

Consensus CDS

CCDS47958.2

UniProtKB/TrEMBL

A0A7P0MP65

Related

ENSP00000354280.6, ENST00000361005.10

Conserved Domains (1) summary

cd00190
Location:1 → 134

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...