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    URGCP upregulator of cell proliferation [ Homo sapiens (human) ]

    Gene ID: 55665, updated on 2-Nov-2024

    Summary

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    Official Symbol
    URGCPprovided by HGNC
    Official Full Name
    upregulator of cell proliferationprovided by HGNC
    Primary source
    HGNC:HGNC:30890
    See related
    Ensembl:ENSG00000106608 MIM:610337; AllianceGenome:HGNC:30890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    URG4
    Summary
    URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 9.7), kidney (RPKM 9.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See URGCP in Genome Data Viewer
    Location:
    7p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (43875913..43926726, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44034204..44085026, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43915512..43966325, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene URGCP-MRPS24 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18130 Neighboring gene uncharacterized LOC124901620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25921 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:43911515-43911690 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18133 Neighboring gene tubulin gamma 1 pseudogene Neighboring gene ubiquitin conjugating enzyme E2 D4 Neighboring gene RNA polymerase II subunit J4 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44010479-44010996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18136 Neighboring gene speedy/RINGO cell cycle regulator family member E1 Neighboring gene Sharpr-MPRA regulatory region 7454 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44070666-44070855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44075983-44076482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18138 Neighboring gene RAS p21 protein activator 4C, pseudogene Neighboring gene long intergenic non-protein coding RNA 957

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel oncogene URG4/URGCP and its role in cancer. Dodurga Y, et al. Gene, 2018 Aug 20. PMID 29775749
    2. URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer. Zhang L, et al. BMC Cancer, 2014 Nov 26. PMID 25427922, Free PMC Article
    3. Temozolomide may induce cell cycle arrest by interacting with URG4/URGCP in SH-SY5Y neuroblastoma cells. Çıtışlı V, et al. Tumour Biol, 2015 Sep. PMID 25835972
    4. URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway. Xing S, et al. BMC Cancer, 2015 May 7. PMID 25947641, Free PMC Article
    5. Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP. Dodurga Y, et al. Tumour Biol, 2016 Feb. PMID 26334619

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Epidermal Growth Factor Mediates Up-regulation of URGCP Oncogene in Human Hepatoma Cancer Cells].
      Title: [Epidermal Growth Factor Mediates Up-regulation of URGCP Oncogene in Human Hepatoma Cancer Cells].
    2. TNF-alpha Induces URG-4/URGCP Gene Expression in Hepatoma Cells through Starvation Dependent Manner.
      Title: TNF-α Induces URG-4/URGCP Gene Expression in Hepatoma Cells through Starvation Dependent Manner.
    3. URG4 overexpression in breast ductal carcinomas is significantly associated with good prognostic parameters.
      Title: URG4 expression in invasive breast carcinoma and its relation to clinicopathological characteristics.
    4. All these results suggested that URGCP accelerates glioma growth through the NF-kappaB/c-myc/miR-16/Cyclin D1/E1 pathway, and both URGCP and miR-16 function as a novel cell cycle regulators in glioma and could be considered as potential targets for glioma therapy.
      Title: Downregulation of miR-16 via URGCP pathway contributes to glioma growth.
    5. Relationship between URG4/URGCP expression and clinicopathologic characteristics were evaluated and significant results were in various cancer types (review).
      Title: A novel oncogene URG4/URGCP and its role in cancer.
    6. miR-519 inhibited URG4 expression by directly binding to the 3'UTR of URG4. miR-519 inhibited Cyclin D1 expression and the phosphorylation level of Rb, and increased p21 and p27 expression, confirming miR-519 blocked G1/S transition.
      Title: miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4/URGCP.
    7. Findings indicate that URGCP plays an important role in promoting NSCLC cell invasion and metastasis by enhancing NF-kappaB-activated MMP-9 expression
      Title: URGCP promotes non-small cell lung cancer invasiveness by activating the NF-κB-MMP-9 pathway.
    8. site-directed mutagenesis of potential SP1 binding sites diminished both DNA-protein complexes and SP1-mediated upregulation of URG-4 promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP that has a pivotal role in cancer progression.
      Title: SP1 is a transcriptional regulator of URG-4/URGCP gene in hepatocytes.
    9. FA caused a decrease in the expression of novel gene URG4/URGCP.
      Title: Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP.
    10. URG4 overexpression increased the resistance to cisplatin-induced apoptosis in bladder cancer.
      Title: URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough URGCP-MRPS24

    Readthrough gene: URGCP-MRPS24, Included gene: MRPS24

    Homology

    Clone Names

    • DKFZp666G166, DKFZp686O0457

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    up-regulator of cell proliferation
    Names
    HBV X protein up-regulated gene 4 protein
    HBxAg up-regulated gene 4 protein
    up-regulated gene 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077663.3 → NP_001071131.1  up-regulator of cell proliferation isoform 3

      See identical proteins and their annotated locations for NP_001071131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest protein (isoform 3).
      Source sequence(s)
      AB040940, AK000661, BX648505
      Consensus CDS
      CCDS47578.1
      UniProtKB/Swiss-Prot
      E9PFF6, Q658M4, Q68DH6, Q6MZZ5, Q8TCY9, Q8WV98, Q9NWR7, Q9P221
      UniProtKB/TrEMBL
      B2RAT5
      Related
      ENSP00000396918.1, ENST00000453200.6
      Conserved Domains (1) summary
      cl21455
      Location:692 → 792
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001077664.3 → NP_001071132.1  up-regulator of cell proliferation isoform 2

      See identical proteins and their annotated locations for NP_001071132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 3. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 3. Variants 2, 4, and 5 encode the same protein (isoform 2).
      Source sequence(s)
      AB040940, AC004985, AK000661, DC336174
      Consensus CDS
      CCDS43572.1
      UniProtKB/TrEMBL
      B7Z7T1
      Conserved Domains (1) summary
      cl21455
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001290075.2 → NP_001277004.1  up-regulator of cell proliferation isoform 2

      See identical proteins and their annotated locations for NP_001277004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 3. The 5'-most initiation codon, as used in variant 3, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG resulting in an isoform (2) with a shorter N-terminus compared to isoform 3. Variants 2, 4, and 5 encode the same protein (isoform 2).
      Source sequence(s)
      AB040940, AK000661, CR749398
      Consensus CDS
      CCDS43572.1
      UniProtKB/TrEMBL
      B7Z7T1
      Related
      ENSP00000392136.1, ENST00000443736.5
      Conserved Domains (1) summary
      cl21455
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001290076.2 → NP_001277005.1  up-regulator of cell proliferation isoform 2

      See identical proteins and their annotated locations for NP_001277005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 3. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 3. Variants 2, 4, and 5 encode the same protein (isoform 2).
      Source sequence(s)
      AB040940, AC004985, AK000661, AK302459, AK314339
      Consensus CDS
      CCDS43572.1
      UniProtKB/TrEMBL
      B7Z7T1
      Conserved Domains (1) summary
      cl21455
      Location:649 → 749
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_017920.5 → NP_060390.3  up-regulator of cell proliferation isoform 1

      See identical proteins and their annotated locations for NP_060390.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. The resulting protein (isoform 1) is shorter, compared to isoform 3.
      Source sequence(s)
      AB040940, AK000661, AK314339
      Consensus CDS
      CCDS47577.1
      UniProtKB/TrEMBL
      B2RAT5
      Related
      ENSP00000384955.3, ENST00000402306.7
      Conserved Domains (1) summary
      cl21455
      Location:683 → 783
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      43875913..43926726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      44034204..44085026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCY9.2 GenPept UniProtKB/Swiss-Prot:Q8TCY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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