VGF VGF nerve growth factor inducible [Homo sapiens (human)] - Gene

Summary

Official Symbol: VGFprovided by HGNC
Official Full Name: VGF nerve growth factor inducibleprovided by HGNC
Primary source: HGNC:HGNC:12684
See related: Ensembl:ENSG00000128564 MIM:602186; AllianceGenome:HGNC:12684
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCG7; SgVII
Summary: This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 14.2) and fat (RPKM 1.5) See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (101162509..101169952, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (102485258..102492805, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (100805790..100808850, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease.
Title: Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease.
Associations of VGF with Neuropathologies and Cognitive Health in Older Adults.
Title: Associations of VGF with Neuropathologies and Cognitive Health in Older Adults.
Structure of AQEE-30 of VGF Neuropeptide in Membrane-Mimicking Environments.
Title: Structure of AQEE-30 of VGF Neuropeptide in Membrane-Mimicking Environments.
Neuronal survival factor VGF promotes chemoresistance and predicts poor prognosis in lung cancers with neuroendocrine feature.
Title: Neuronal survival factor VGF promotes chemoresistance and predicts poor prognosis in lung cancers with neuroendocrine feature.
Low VGF is associated with executive dysfunction in patients with major depressive disorder.
Title: Low VGF is associated with executive dysfunction in patients with major depressive disorder.
Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
Title: Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Title: Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Serum VGF levels were significantly lower in MDD patients but higher in BD patients compared with HC (both PTukey < 0.01). No correlation was found between serum VGF levels and any data of subjects.
Title: Higher serum VGF protein levels discriminate bipolar depression from major depressive disorder.
H19 is a promising prognostic factor in Pancreatic neuroendocrine neoplasms (pNENs) with malignant behaviors and functions as an oncogene via the VGF-mediated PI3K/AKT/CREB pathway. In addition, our study implies that VGF may also serve as a candidate prognostic biomarker and therapeutic target in pNENs.
Title: lncRNA H19 binds VGF and promotes pNEN progression via PI3K/AKT/CREB signaling.
Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression.
Title: Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in generation of precursor metabolites and energy	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cold	IEA Inferred from Electronic Annotation more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurosecretory protein VGF

Names: neuro-endocrine specific protein VGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003378.4 → NP_003369.2 neurosecretory protein VGF precursor

See identical proteins and their annotated locations for NP_003369.2

Status: REVIEWED

Source sequence(s)

BC036537, BC063835

Consensus CDS

CCDS5712.1

UniProtKB/Swiss-Prot

O15240, Q9UDW8

Related

ENSP00000249330.2, ENST00000249330.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

101162509..101169952 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011516549.4 → XP_011514851.1 neurosecretory protein VGF isoform X1

See identical proteins and their annotated locations for XP_011514851.1

UniProtKB/Swiss-Prot

O15240, Q9UDW8
XM_005250561.6 → XP_005250618.1 neurosecretory protein VGF isoform X1

See identical proteins and their annotated locations for XP_005250618.1

UniProtKB/Swiss-Prot

O15240, Q9UDW8

Related

ENSP00000400884.2, ENST00000445482.2

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

102485258..102492805 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358937.1 → XP_054214912.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

O15240, Q9UDW8
XM_054358935.1 → XP_054214910.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

O15240, Q9UDW8
XM_054358936.1 → XP_054214911.1 neurosecretory protein VGF isoform X1

UniProtKB/Swiss-Prot

O15240, Q9UDW8