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    GSTT1 glutathione S-transferase theta 1 [ Homo sapiens (human) ]

    Gene ID: 2952, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GSTT1provided by HGNC
    Official Full Name
    glutathione S-transferase theta 1provided by HGNC
    Primary source
    HGNC:HGNC:4641
    See related
    MIM:600436; AllianceGenome:HGNC:4641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Annotation information
    Annotation category: only annotated on alternate loci in reference assembly
    Orthologs
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    Genomic context

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    See GSTT1 in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 (ALT_REF_LOCI_1) NT_187633.1 (270308..278486, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24441300..24449468, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24376133..24384311, complement)

    NT_187633.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase theta 1 pseudogene Neighboring gene D-dopachrome tautomerase-like Neighboring gene GSTT1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24382419-24382933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24382934-24383447 Neighboring gene glutathione S-transferase theta pseudogene 2 Neighboring gene uncharacterized LOC105372959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: a comprehensive meta-analysis. Fang M, et al. Tumour Biol, 2013 Oct. PMID 23696026
    2. GSTT1 genetic polymorphism and susceptibility to childhood acute lymphoblastic leukemia: a meta-analysis. Xu LY, et al. Tumour Biol, 2014 Feb. PMID 24282086
    3. Association between glutathione S-transferase T1 null genotype and risk of lung cancer: a meta-analysis of 55 studies. Yang H, et al. Tumour Biol, 2014 Mar. PMID 24189890
    4. GSTT1 copy number gain and ZNF overexpression are predictors of poor response to imatinib in gastrointestinal stromal tumors. Lee EJ, et al. PLoS One, 2013. PMID 24124608, Free PMC Article
    5. Association between glutathione S-transferase T1 null genotype and glioma susceptibility: a meta-analysis. Zhang B, et al. Tumour Biol, 2014 Mar. PMID 24122206

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of mRNA expression and polymorphism of antioxidant glutathione-S-transferase (GSTM1 and GSTT1) genes with the risk of Gestational Diabetes Mellitus (GDM).
      Title: Association of mRNA expression and polymorphism of antioxidant glutathione-S-transferase (GSTM1 and GSTT1) genes with the risk of Gestational Diabetes Mellitus (GDM).
    2. The potential influence of GSTT1 null genetic polymorphism on coronary artery disease: A pilot study in a South Indian cohort.
      Title: The potential influence of GSTT1 null genetic polymorphism on coronary artery disease: A pilot study in a South Indian cohort.
    3. Genetic Polymorphisms in Glutathione S-Transferase (GST) Gene and Their Correlation with Toxicity of Chemotherapy in Breast Cancer Patients.
      Title: Genetic Polymorphisms in Glutathione S-Transferase (GST) Gene and Their Correlation with Toxicity of Chemotherapy in Breast Cancer Patients.
    4. Association of Glutathione Transferase M1, T1, P1 and A1 Gene Polymorphism and Susceptibility to IgA Vasculitis.
      Title: Association of Glutathione Transferase M1, T1, P1 and A1 Gene Polymorphism and Susceptibility to IgA Vasculitis.
    5. Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study.
      Title: Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study.
    6. GSTs genetic polymorphism, gene-environment interaction and association with gallbladder cancer risk in North Indian population: A case-controlled study.
      Title: GSTs genetic polymorphism, gene-environment interaction and association with gallbladder cancer risk in North Indian population: A case-controlled study.
    7. Association of Oral Submucous Fibrosis Risk with <em>GSTM1</em> and <em>GSTT1</em> Gene Polymorphisms.
      Title: Association of Oral Submucous Fibrosis Risk with <em>GSTM1</em> and <em>GSTT1</em> Gene Polymorphisms.
    8. Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.
      Title: Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.
    9. Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.
      Title: Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.
    10. Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis.
      Title: Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (1089)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ18180, DKFZp762N226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase theta-1
    Names
    GST class-theta-1
    glutathione transferase T1-1
    NP_000844.2
    NP_001280736.1
    NP_001280737.1
    NP_001280738.1
    NP_001280739.1
    NP_001280740.1
    NP_001280741.1
    NP_001280742.1
    NP_001280743.1
    XP_054181554.1
    XP_054185431.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000853.4 → NP_000844.2  glutathione S-transferase theta-1 isoform a

      See identical proteins and their annotated locations for NP_000844.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AP000351
      UniProtKB/Swiss-Prot
      O00226, P30711, Q5TZY2, Q6IC69, Q969K8, Q96IY3
      Conserved Domains (2) summary
      cd03183
      Location:91 → 216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    2. NM_001293807.1 → NP_001280736.1  glutathione S-transferase theta-1 isoform b

      See identical proteins and their annotated locations for NP_001280736.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon but lacks a different exon, which results in a frameshifted segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AF435971, BG536639, CA306446, CA487832, DA900601
      UniProtKB/TrEMBL
      A0A0G2JRQ5
      Conserved Domains (2) summary
      cd03183
      Location:103 → 202
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cl00388
      Location:3 → 37
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001293808.1 → NP_001280737.1  glutathione S-transferase theta-1 isoform c

      See identical proteins and their annotated locations for NP_001280737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
      Source sequence(s)
      AJ874719, CA306446, CA487832
      UniProtKB/Swiss-Prot
      P30711
      UniProtKB/TrEMBL
      Q4GZS9
      Conserved Domains (1) summary
      cl02776
      Location:1 → 98
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    4. NM_001293809.1 → NP_001280738.1  glutathione S-transferase theta-1 isoform c

      See identical proteins and their annotated locations for NP_001280738.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
      Source sequence(s)
      CA306446, CA487832, CD701199
      UniProtKB/Swiss-Prot
      P30711
      Conserved Domains (1) summary
      cl02776
      Location:1 → 98
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    5. NM_001293810.1 → NP_001280739.1  glutathione S-transferase theta-1 isoform c

      See identical proteins and their annotated locations for NP_001280739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
      Source sequence(s)
      CA306446, CA487832, CR456499
      UniProtKB/Swiss-Prot
      P30711
      Conserved Domains (1) summary
      cl02776
      Location:1 → 98
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    6. NM_001293811.1 → NP_001280740.1  glutathione S-transferase theta-1 isoform c

      See identical proteins and their annotated locations for NP_001280740.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
      Source sequence(s)
      BF343733, CA306446, CA487832
      UniProtKB/Swiss-Prot
      P30711
      Conserved Domains (1) summary
      cl02776
      Location:1 → 98
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    7. NM_001293812.1 → NP_001280741.1  glutathione S-transferase theta-1 isoform c

      See identical proteins and their annotated locations for NP_001280741.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.
      Source sequence(s)
      BX401239, CA306446, CA487832
      UniProtKB/Swiss-Prot
      P30711
      Conserved Domains (1) summary
      cl02776
      Location:1 → 98
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    8. NM_001293813.1 → NP_001280742.1  glutathione S-transferase theta-1 isoform d

      See identical proteins and their annotated locations for NP_001280742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AA298437, CA306446, CA487832
      UniProtKB/TrEMBL
      A0A0G2JRN4
      Conserved Domains (1) summary
      cd03050
      Location:3 → 67
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    9. NM_001293814.1 → NP_001280743.1  glutathione S-transferase theta-1 isoform e

      See identical proteins and their annotated locations for NP_001280743.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks three alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AJ867758, CA306446, CA487832
      UniProtKB/TrEMBL
      A0A0G2JQM5, Q4W251
      Conserved Domains (1) summary
      cl00388
      Location:3 → 37
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      270308..278486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329456.1 → XP_054185431.1  glutathione S-transferase theta-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24441300..24449468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325579.1 → XP_054181554.1  glutathione S-transferase theta-1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30711.4 GenPept UniProtKB/Swiss-Prot:P30711

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