Cdc34 cell division cycle 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc34provided by MGI
Official Full Name: cell division cycle 34provided by MGI
Primary source: MGI:MGI:102657
See related: Ensembl:ENSMUSG00000020307 AllianceGenome:MGI:102657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UBE2R1; E2-CDC34
Summary: Enables ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including cellular response to interferon-beta; negative regulation of cAMP-mediated signaling; and protein ubiquitination. Predicted to be located in cytosol and nuclear speck. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 167.9), placenta adult (RPKM 79.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79518029..79524232)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79682193..79688398)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inclusion body assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to growth factor	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 R1

Names: (E3-independent) E2 ubiquitin-conjugating enzyme R1; E2 ubiquitin-conjugating enzyme R1; cell division cycle 34 homolog; ubiquitin-conjugating enzyme Cdc34; ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; ubiquitin-protein ligase R1

NP_001346746.1

EC 2.3.2.23

EC 2.3.2.24

NP_001346747.1

EC 2.3.2.23

EC 2.3.2.24

NP_808281.1

EC 2.3.2.23

EC 2.3.2.24

XP_017169376.1

EC 2.3.2.23

EC 2.3.2.24

XP_017169377.1

EC 2.3.2.23

EC 2.3.2.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359817.1 → NP_001346746.1 ubiquitin-conjugating enzyme E2 R1 isoform 2

Status: VALIDATED

Source sequence(s)

AC151828, BE988402, BY083281, BY114161, CA320111

Consensus CDS

CCDS88049.1

UniProtKB/TrEMBL

A0A1W2P7U1

Related

ENSMUSP00000151763.2, ENSMUST00000219791.2

Conserved Domains (1) summary

cd00195
Location:11 → 125

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001359818.1 → NP_001346747.1 ubiquitin-conjugating enzyme E2 R1 isoform 3

Status: VALIDATED

Source sequence(s)

AC151828, BE988402, BY114161, CA320111, CX210748

UniProtKB/TrEMBL

A0A1W2P7U9

Related

ENSMUSP00000152000.2, ENSMUST00000218964.2

Conserved Domains (1) summary

cd00195
Location:11 → 162

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_177613.2 → NP_808281.1 ubiquitin-conjugating enzyme E2 R1 isoform 1

See identical proteins and their annotated locations for NP_808281.1

Status: VALIDATED

Source sequence(s)

BC039160

Consensus CDS

CCDS23983.1

UniProtKB/Swiss-Prot

Q505K8, Q8CFI2

UniProtKB/TrEMBL

A0A087WP01

Related

ENSMUSP00000020550.6, ENSMUST00000020550.13

Conserved Domains (1) summary

cd00195
Location:11 → 162

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79518029..79524232

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313888.3 → XP_017169377.1 ubiquitin-conjugating enzyme E2 R1 isoform X1

UniProtKB/Swiss-Prot

Q505K8, Q8CFI2

UniProtKB/TrEMBL

A0A087WP01

Conserved Domains (1) summary

cd00195
Location:11 → 162

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
XM_017313887.2 → XP_017169376.1 ubiquitin-conjugating enzyme E2 R1 isoform X1

UniProtKB/Swiss-Prot

Q505K8, Q8CFI2

UniProtKB/TrEMBL

A0A087WP01

Conserved Domains (1) summary

cd00195
Location:11 → 162

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...