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    Tpd52 tumor protein D52 [ Mus musculus (house mouse) ]

    Gene ID: 21985, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tpd52provided by MGI
    Official Full Name
    tumor protein D52provided by MGI
    Primary source
    MGI:MGI:107749
    See related
    Ensembl:ENSMUSG00000027506 AllianceGenome:MGI:107749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mD52
    Summary
    Enables protein homodimerization activity. Acts upstream of or within positive regulation of cell population proliferation. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 34.0), colon adult (RPKM 25.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpd52 in Genome Data Viewer
    Location:
    3 A1; 3 2.23 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (8991590..9069824, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (8926530..9005393, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene STARR-positive B cell enhancer mm9_chr3:8916344-8916645 Neighboring gene predicted gene, 52600 Neighboring gene STARR-seq mESC enhancer starr_06865 Neighboring gene predicted gene, 52601 Neighboring gene STARR-seq mESC enhancer starr_06870 Neighboring gene STARR-seq mESC enhancer starr_06875 Neighboring gene STARR-positive B cell enhancer ABC_E7899 Neighboring gene STARR-seq mESC enhancer starr_06879 Neighboring gene STARR-seq mESC enhancer starr_06880 Neighboring gene STARR-seq mESC enhancer starr_06881 Neighboring gene predicted gene, 46832 Neighboring gene predicted gene, 54188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The tumor protein D52 family: many pieces, many puzzles. Boutros R, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555543
    2. Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes. Ito C, et al. Biomed Res Int, 2017. PMID 28798933, Free PMC Article
    3. Induction of tumorigenesis and metastasis by the murine orthologue of tumor protein D52. Lewis JD, et al. Mol Cancer Res, 2007 Feb. PMID 17314271
    4. TPD52 expression increases neutral lipid storage within cultured cells. Kamili A, et al. J Cell Sci, 2015 Sep 1. PMID 26183179, Free PMC Article
    5. Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene? Byrne JA, et al. Tumour Biol, 2014 Aug. PMID 24798974

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein D52
    NP_001020432.1
    NP_001020433.1
    NP_001020434.1
    NP_001020435.1
    NP_001344001.1
    NP_001344002.1
    NP_001344003.1
    NP_033438.1
    XP_006530128.1
    XP_006530129.1
    XP_006530130.1
    XP_006530131.1
    XP_006530134.1
    XP_011246444.1
    XP_011246445.1
    XP_011246446.1
    XP_011246447.1
    XP_030108413.1
    XP_036018910.1
    XP_036018911.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025261.3 → NP_001020432.1  tumor protein D52 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Consensus CDS
      CCDS38387.1
      UniProtKB/TrEMBL
      F8WHQ1
      Related
      ENSMUSP00000091943.5, ENSMUST00000094381.11
      Conserved Domains (1) summary
      pfam04201
      Location:51 → 232
      TPD52; Tumour protein D52 family

    2. NM_001025262.3 → NP_001020433.1  tumor protein D52 isoform 2

      See identical proteins and their annotated locations for NP_001020433.1

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Consensus CDS
      CCDS38386.1
      UniProtKB/Swiss-Prot
      Q545M5, Q62393, Q8CCU1, Q8K564, Q99KP8
      Related
      ENSMUSP00000088913.6, ENSMUST00000091354.12
      Conserved Domains (1) summary
      pfam04201
      Location:51 → 209
      TPD52; Tumour protein D52 family

    3. NM_001025263.3 → NP_001020434.1  tumor protein D52 isoform 3

      See identical proteins and their annotated locations for NP_001020434.1

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Consensus CDS
      CCDS38384.1
      UniProtKB/TrEMBL
      D3Z125
      Related
      ENSMUSP00000088914.6, ENSMUST00000091355.12
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 184
      TPD52; Tumour protein D52 family

    4. NM_001025264.3 → NP_001020435.1  tumor protein D52 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Consensus CDS
      CCDS38385.1
      UniProtKB/TrEMBL
      D3Z125, E9PUA7
      Related
      ENSMUSP00000066826.8, ENSMUST00000063496.14
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 179
      TPD52; Tumour protein D52 family

    5. NM_001357072.1 → NP_001344001.1  tumor protein D52 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Conserved Domains (1) summary
      pfam04201
      Location:152 → 301
      TPD52; tumor protein D52 family

    6. NM_001357073.1 → NP_001344002.1  tumor protein D52 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Conserved Domains (1) summary
      pfam04201
      Location:108 → 289
      TPD52; tumor protein D52 family

    7. NM_001357074.2 → NP_001344003.1  tumor protein D52 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      UniProtKB/TrEMBL
      D3Z125
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 193
      TPD52; tumor protein D52 family

    8. NM_001428700.1 → NP_001415629.1  tumor protein D52 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056

    9. NM_001428701.1 → NP_001415630.1  tumor protein D52 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056

    10. NM_001428702.1 → NP_001415631.1  tumor protein D52 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056

    11. NM_001428703.1 → NP_001415632.1  tumor protein D52 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056

    12. NM_001428705.1 → NP_001415634.1  tumor protein D52 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056

    13. NM_009412.4 → NP_033438.1  tumor protein D52 isoform 5

      See identical proteins and their annotated locations for NP_033438.1

      Status: VALIDATED

      Source sequence(s)
      AC133935, AC161056
      Consensus CDS
      CCDS50860.1
      UniProtKB/TrEMBL
      D3Z125
      Related
      ENSMUSP00000112830.2, ENSMUST00000120143.8
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 170
      TPD52; Tumour protein D52 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      8991590..9069824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252553.2 → XP_030108413.1  tumor protein D52 isoform X9

      Related
      ENSMUSP00000119899.2, ENSMUST00000134788.8
      Conserved Domains (1) summary
      pfam04201
      Location:49 → 207
      TPD52; tumor protein D52 family

    2. XM_011248144.2 → XP_011246446.1  tumor protein D52 isoform X3

      UniProtKB/TrEMBL
      D3Z7X7
      Conserved Domains (1) summary
      pfam04201
      Location:60 → 218
      TPD52; tumor protein D52 family

    3. XM_011248142.2 → XP_011246444.1  tumor protein D52 isoform X1

      UniProtKB/TrEMBL
      D3Z7X7
      Conserved Domains (1) summary
      pfam04201
      Location:60 → 232
      TPD52; tumor protein D52 family

    4. XM_011248143.2 → XP_011246445.1  tumor protein D52 isoform X2

      UniProtKB/TrEMBL
      D3Z7X7
      Conserved Domains (1) summary
      pfam04201
      Location:60 → 227
      TPD52; tumor protein D52 family

    5. XM_006530067.5 → XP_006530130.1  tumor protein D52 isoform X7

      Conserved Domains (1) summary
      pfam04201
      Location:51 → 223
      TPD52; tumor protein D52 family

    6. XM_006530068.5 → XP_006530131.1  tumor protein D52 isoform X8

      Conserved Domains (1) summary
      pfam04201
      Location:51 → 218
      TPD52; tumor protein D52 family

    7. XM_036163017.1 → XP_036018910.1  tumor protein D52 isoform X11

      UniProtKB/TrEMBL
      D3Z637
      Related
      ENSMUSP00000113368.2, ENSMUST00000121038.8
      Conserved Domains (1) summary
      pfam04201
      Location:21 → 161
      TPD52; tumor protein D52 family

    8. XM_006530066.5 → XP_006530129.1  tumor protein D52 isoform X5

      Conserved Domains (1) summary
      pfam04201
      Location:49 → 230
      TPD52; tumor protein D52 family

    9. XM_036163018.1 → XP_036018911.1  tumor protein D52 isoform X12

      Conserved Domains (1) summary
      pfam04201
      Location:12 → 128
      TPD52; tumor protein D52 family

    10. XM_011248145.3 → XP_011246447.1  tumor protein D52 isoform X6

      UniProtKB/TrEMBL
      D3Z7X7
      Conserved Domains (1) summary
      pfam04201
      Location:60 → 176
      TPD52; tumor protein D52 family

    11. XM_006530065.5 → XP_006530128.1  tumor protein D52 isoform X4

      Conserved Domains (1) summary
      pfam04201
      Location:56 → 237
      TPD52; tumor protein D52 family

    12. XM_006530071.3 → XP_006530134.1  tumor protein D52 isoform X10

      UniProtKB/TrEMBL
      D3Z637
      Conserved Domains (1) summary
      pfam04201
      Location:21 → 170
      TPD52; tumor protein D52 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62393.2 GenPept UniProtKB/Swiss-Prot:Q62393

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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