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    CDCA3 cell division cycle associated 3 [ Homo sapiens (human) ]

    Gene ID: 83461, updated on 14-Nov-2024

    Summary

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    Official Symbol
    CDCA3provided by HGNC
    Official Full Name
    cell division cycle associated 3provided by HGNC
    Primary source
    HGNC:HGNC:14624
    See related
    Ensembl:ENSG00000111665 MIM:607749; AllianceGenome:HGNC:14624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRCC8; TOME1; TOME-1
    Summary
    Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 6.4), duodenum (RPKM 3.8) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDCA3 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6844798..6851286, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6854092..6860585, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6953962..6960450, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6936229-6936797 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6960952-6961912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4186 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6974948-6975610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6975611-6976272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6979885-6980470 Neighboring gene triosephosphate isomerase 1 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.
      Title: Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.
    2. MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells.
      Title: MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells.
    3. CDCA3 exhibits a role in promoting the progression of ovarian cancer.
      Title: CDCA3 exhibits a role in promoting the progression of ovarian cancer.
    4. MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3.
      Title: MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3.
    5. LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.
      Title: LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.
    6. Prognostic value of CDCA3 in kidney renal papillary cell carcinoma.
      Title: Prognostic value of CDCA3 in kidney renal papillary cell carcinoma.
    7. Suppression of CDCA3 inhibits prostate cancer progression via NFkappaB/cyclin D1 signaling inactivation and p21 accumulation.
      Title: Suppression of CDCA3 inhibits prostate cancer progression via NF‑κB/cyclin D1 signaling inactivation and p21 accumulation.
    8. Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.
      Title: Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.
    9. Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.
      Title: Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.
    10. Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.
      Title: Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2577

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 3
    Names
    gene-rich cluster protein C8
    trigger of mitotic entry protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297602.3 → NP_001284531.1  cell division cycle-associated protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      U47924
      Consensus CDS
      CCDS76512.1
      UniProtKB/TrEMBL
      B2R749, J3KMY0
      Related
      ENSP00000229265.5, ENST00000229265.10
      Conserved Domains (1) summary
      PHA03247
      Location:2 → 156
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001297603.3 → NP_001284532.1  cell division cycle-associated protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001284532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' structure, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a distinct C-terminus, and is shorter, compared to isoform 1.
      Source sequence(s)
      AK092246, AK291421, U47924
      Consensus CDS
      CCDS76513.1
      UniProtKB/TrEMBL
      F8WDL1
      Related
      ENSP00000415142.2, ENST00000422785.7

    3. NM_001297604.3 → NP_001284533.1  cell division cycle-associated protein 3 isoform 4

      See identical proteins and their annotated locations for NP_001284533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (4) has a distinct C-terminus, and is shorter, compared to isoform 1.
      Source sequence(s)
      AK291421, BQ961607, U47924
      Consensus CDS
      CCDS73428.1
      UniProtKB/TrEMBL
      F5GX58
      Related
      ENSP00000441120.1, ENST00000540683.1

    4. NM_001331019.2 → NP_001317948.1  cell division cycle-associated protein 3 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the both the 5' and 3' coding regions and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus and distict, shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK291421, AV714087, U47924
      UniProtKB/Swiss-Prot
      Q99618

    5. NM_031299.7 → NP_112589.1  cell division cycle-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_112589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK291421, U47924
      Consensus CDS
      CCDS8565.1
      UniProtKB/Swiss-Prot
      A8K5V6, D3DUS6, Q99618
      UniProtKB/TrEMBL
      B2R749
      Related
      ENSP00000442068.1, ENST00000538862.7

    RNA

    1. NR_123727.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK291421, DA735127, U47924

    2. NR_138531.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an exon in the 5' region and uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 6, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      U47924

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      6844798..6851286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429628.1 → XP_047285584.1  cell division cycle-associated protein 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      6854092..6860585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373379.1 → XP_054229354.1  cell division cycle-associated protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99618.1 GenPept UniProtKB/Swiss-Prot:Q99618

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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