U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sbp spermine binding protein [ Mus musculus (house mouse) ]

    Gene ID: 20234, updated on 14-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sbpprovided by MGI
    Official Full Name
    spermine binding proteinprovided by MGI
    Primary source
    MGI:MGI:106021
    See related
    Ensembl:ENSMUSG00000024128 AllianceGenome:MGI:106021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p25
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in prostate gland dorsolateral lobe and ventral prostate gland. Orthologous to human ZG16B (zymogen granule protein 16B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sbp in Genome Data Viewer
    Location:
    17 A3.3; 17 12.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24141525..24164577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23922551..23945603)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42067 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene predicted gene, 41545 Neighboring gene demilune cell and parotid protein 3 Neighboring gene spermine binding protein-like Neighboring gene predicted gene, 41546 Neighboring gene serine protease 30

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Fischer A, et al. Neuron, 2005 Dec 8. PMID 16337919
    2. Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Mills JS, et al. Nucleic Acids Res, 1987 Oct 12. PMID 3502715, Free PMC Article
    3. Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Joesting MS, et al. Dev Biol, 2008 May 1. PMID 18371946, Free PMC Article
    4. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prostatic spermine-binding protein
    Names
    major prostatic secretory glycoprotein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384094.1 → NP_001371023.1  prostatic spermine-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC110262
      UniProtKB/Swiss-Prot
      P15501
      UniProtKB/TrEMBL
      Q544L5, S4R244
      Related
      ENSMUSP00000138422.2, ENSMUST00000181985.8
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    2. NM_001384097.1 → NP_001371026.1  prostatic spermine-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC110262
      UniProtKB/Swiss-Prot
      P15501
      UniProtKB/TrEMBL
      Q544L5, S4R244
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    3. NM_001384098.1 → NP_001371027.1  prostatic spermine-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC110262
      UniProtKB/Swiss-Prot
      P15501
      UniProtKB/TrEMBL
      Q544L5, S4R244
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    4. NM_001384100.1 → NP_001371029.1  prostatic spermine-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC110262
      UniProtKB/Swiss-Prot
      P15501
      UniProtKB/TrEMBL
      Q544L5, S4R244
      Related
      ENSMUSP00000024940.5, ENSMUST00000024940.11
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    5. NM_011321.4 → NP_035451.1  prostatic spermine-binding protein precursor

      See identical proteins and their annotated locations for NP_035451.1

      Status: VALIDATED

      Source sequence(s)
      AC110262
      Consensus CDS
      CCDS57056.1
      UniProtKB/Swiss-Prot
      P15501
      UniProtKB/TrEMBL
      Q544L5, S4R244
      Related
      ENSMUSP00000138219.2, ENSMUST00000183252.8
      Conserved Domains (1) summary
      cd09611
      Location:22 → 150
      Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24141525..24164577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15501.1 GenPept UniProtKB/Swiss-Prot:P15501

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous