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    Acp2 acid phosphatase 2, lysosomal [ Mus musculus (house mouse) ]

    Gene ID: 11432, updated on 28-Oct-2024

    Summary

    Official Symbol
    Acp2provided by MGI
    Official Full Name
    acid phosphatase 2, lysosomalprovided by MGI
    Primary source
    MGI:MGI:87882
    See related
    Ensembl:ENSMUSG00000002103 AllianceGenome:MGI:87882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAP; Acp-2
    Summary
    The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 14.6), ovary adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Acp2 in Genome Data Viewer
    Location:
    2 E1; 2 50.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91033157..91044443)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91202812..91214098)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MAP-kinase activating death domain Neighboring gene STARR-positive B cell enhancer mm9_chr2:91023256-91023557 Neighboring gene STARR-positive B cell enhancer ABC_E4478 Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E9070 Neighboring gene predicted gene, 23390 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91057269-91057452 Neighboring gene damage specific DNA binding protein 2 Neighboring gene RIKEN cDNA A330069E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E8985 Neighboring gene predicted gene, 31054

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysosomal acid phosphatase
    NP_001343996.1
    NP_031413.1
    XP_011237559.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357067.1NP_001343996.1  lysosomal acid phosphatase isoform 1x precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AK128963, AK133756, AL691450, AW061158, BQ445129, CD741498
      Consensus CDS
      CCDS89516.1
      UniProtKB/TrEMBL
      A0A5F8MPS7, Q3U4F3
      Related
      ENSMUSP00000159089.2, ENSMUST00000238832.2
      Conserved Domains (1) summary
      cd07061
      Location:33330
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. NM_007387.2NP_031413.1  lysosomal acid phosphatase isoform 1 precursor

      See identical proteins and their annotated locations for NP_031413.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      AK128963, AK133756, AL691450, AW061158, BQ445129, CD741498
      Consensus CDS
      CCDS16427.1
      UniProtKB/Swiss-Prot
      P24638, Q8QZT5
      UniProtKB/TrEMBL
      Q3U4F3
      Related
      ENSMUSP00000159053.2, ENSMUST00000239169.2
      Conserved Domains (1) summary
      cd07061
      Location:33330
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91033157..91044443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239257.3XP_011237559.1  lysosomal acid phosphatase isoform X1

      UniProtKB/TrEMBL
      Q3U4F3
      Conserved Domains (1) summary
      cd07061
      Location:18312
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RNA

    1. XR_003950055.2 RNA Sequence