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    TMEM92 transmembrane protein 92 [ Homo sapiens (human) ]

    Gene ID: 162461, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM92provided by HGNC
    Official Full Name
    transmembrane protein 92provided by HGNC
    Primary source
    HGNC:HGNC:26579
    See related
    Ensembl:ENSG00000167105 MIM:619604; AllianceGenome:HGNC:26579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in small intestine (RPKM 10.1), duodenum (RPKM 7.9) and 7 other tissues See more
    Orthologs
    all
    NEW
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    Genomic context

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    See TMEM92 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (50271406..50281485)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (51138488..51148563)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48348767..48358846)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48335091-48335661 Neighboring gene uncharacterized LOC124904028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8692 Neighboring gene Sharpr-MPRA regulatory region 4171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48354331-48354878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48354879-48355426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8693 Neighboring gene TMEM92 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr17:48380397-48381379 Neighboring gene NANOG hESC enhancer GRCh37_chr17:48388769-48389287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12381 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:48395384-48395963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48395964-48396542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8696 Neighboring gene Sharpr-MPRA regulatory region 10047 Neighboring gene xylosyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition. Lin MZ, et al. Tissue Cell, 2020 Dec. PMID 32835947
    2. A prognostic 4-gene expression signature for squamous cell lung carcinoma. Li J, et al. J Cell Physiol, 2017 Dec. PMID 28160492
    3. MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer. Listing H, et al. Br J Cancer, 2015 Jan 6. PMID 25422915, Free PMC Article
    4. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. Alazami AM, et al. Cell Rep, 2015 Jan 13. PMID 25558065
    5. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Pei J, et al. Cell Signal, 2012 Mar. PMID 22120523, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition.
      Title: Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ33318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 92

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054733.1 RefSeqGene

      Range
      8061..15080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168215.2 → NP_001161687.1  transmembrane protein 92 precursor

      See identical proteins and their annotated locations for NP_001161687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC015909, AK090637, AW293202, AY358204
      Consensus CDS
      CCDS11562.1
      UniProtKB/Swiss-Prot
      Q6UXU6, Q8NBF0
      Related
      ENSP00000300433.3, ENST00000300433.7
      Conserved Domains (1) summary
      pfam11669
      Location:34 → 127
      WBP-1; WW domain-binding protein 1

    2. NM_153229.3 → NP_694961.2  transmembrane protein 92 precursor

      See identical proteins and their annotated locations for NP_694961.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC015909, AK090637, AW293202, DB072318
      Consensus CDS
      CCDS11562.1
      UniProtKB/Swiss-Prot
      Q6UXU6, Q8NBF0
      Related
      ENSP00000425144.1, ENST00000507382.2
      Conserved Domains (1) summary
      pfam11669
      Location:34 → 127
      WBP-1; WW domain-binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      50271406..50281485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      51138488..51148563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UXU6.1 GenPept UniProtKB/Swiss-Prot:Q6UXU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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