EIF4B eukaryotic translation initiation factor 4B [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF4Bprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 4Bprovided by HGNC
Primary source: HGNC:HGNC:3285
See related: Ensembl:ENSG00000063046 MIM:603928; AllianceGenome:HGNC:3285
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EIF-4B; PRO1843
Summary: Enables RNA binding activity. Predicted to be involved in regulation of translational initiation. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (53006456..53042215)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (52970957..53006612)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (53400240..53435999)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs.
Title: Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs.
Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
Title: Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B.
Title: Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B.
DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis.
Title: DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis.
CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4beta.
Title: CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4β.
eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.
Title: eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.
Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
Title: Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated amyotrophic lateral sclerosis.
Title: eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.
High EIF4B expression is associated with Malignant Grade in Prostate Cancer.
Title: Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma.
Title: Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies new prostate cancer susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Cellular biotinylated eukaryotic translation initiation factor 4B (EIF4B) protein is incorporated into HIV-1 Gag virus-like particles	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

D8S2279 (e-PCR)
- UniSTS:473907

RH68256 (e-PCR)
- UniSTS:88184

GDB:451628 (e-PCR)
- UniSTS:157330

D16S2650 (e-PCR)
- UniSTS:152257

DXS6986E (e-PCR)
- UniSTS:89026

EIF4B (e-PCR)
- UniSTS:504004

EIF4E_1193 (e-PCR)
- UniSTS:277199

G64236 (e-PCR)
- UniSTS:166647

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA strand annealing activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA strand-exchange activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal small subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in eukaryotic translation initiation factor 4F complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translational initiation	TAS Traceable Author Statement more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic translation initiation factor 4F complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300821.3 → NP_001287750.1 eukaryotic translation initiation factor 4B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC068888

Consensus CDS

CCDS73474.1

UniProtKB/TrEMBL

B4DRM3, E7EX17

Related

ENSP00000388806.3, ENST00000420463.7

Conserved Domains (2) summary

COG0724
Location:83 → 190

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12402
Location:95 → 171

RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
NM_001330654.2 → NP_001317583.1 eukaryotic translation initiation factor 4B isoform 3

Status: VALIDATED

Source sequence(s)

AC068888

Consensus CDS

CCDS86303.1

UniProtKB/TrEMBL

B4DRM3

Related

ENSP00000412530.3, ENST00000416762.7
NM_001417.7 → NP_001408.2 eukaryotic translation initiation factor 4B isoform 2

See identical proteins and their annotated locations for NP_001408.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC068888

Consensus CDS

CCDS41788.1

UniProtKB/Swiss-Prot

B4DS13, P23588, Q4G0E3, Q53HQ2, Q6GPH5, Q6IB46, Q8WYK5

UniProtKB/TrEMBL

B4DRM3

Related

ENSP00000262056.9, ENST00000262056.14

Conserved Domains (3) summary

PRK12678
Location:158 → 273

PRK12678; transcription termination factor Rho; Provisional

PTZ00108
Location:372 → 608

PTZ00108; DNA topoisomerase 2-like protein; Provisional

cd12402
Location:94 → 175

RRM_eIF4B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

53006456..53042215

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

52970957..53006612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_018507.1: Suppressed sequence

Description

NM_018507.1: This RefSeq was permanently suppressed because it is primarily 3'' UTR sequence and it is on the wrong strand compared to other mRNA transcripts for the gene.