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    LNP1 Lnp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856599, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LNP1
    Official Full Name
    Lnp1p
    Primary source
    SGD:S000001235
    Locus tag
    YHR192W
    See related
    AllianceGenome:SGD:S000001235; FungiDB:YHR192W; VEuPathDB:YHR192W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity. Involved in endoplasmic reticulum tubular network organization; response to endoplasmic reticulum stress; and reticulophagy. Located in endoplasmic reticulum tubular network. Orthologous to human LNPK (lunapark, ER junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LNP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (486826..487662)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase Neighboring gene Ctf8p Neighboring gene Egd2p Neighboring gene Mdm31p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Chen S, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915089, Free PMC Article
    2. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. Chen S, et al. Nat Cell Biol, 2012 Jun 24. PMID 22729086, Free PMC Article
    3. Reticulons Regulate the ER Inheritance Block during ER Stress. Piña FJ, et al. Dev Cell, 2016 May 9. PMID 27117666, Free PMC Article
    4. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Casey AK, et al. Mol Biol Cell, 2015 Aug 1. PMID 26041935, Free PMC Article
    5. A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Stevenson LF, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274415, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lnp1 is needed to stabilize the actin-dependent remodeling of the ER that is essential for ER-phagy.
      Title: ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network.
    2. we identify a NE role in Saccharomyces cerevisiae for Lnp1 and Sey1, proteins required for proper cortical ER formation.
      Title: Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lnp1p
    NP_012062.1
    • Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; required for reticulophagy where it is proposed to stabilize the actin-dependent remodeling of the ER; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      486826..487662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179323.1 → NP_012062.1  TPA: Lnp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLE0, P38878
      UniProtKB/TrEMBL
      A6ZT98, B3LSV3, B5VKC0, C7GRL4, C8Z9Z1
      Conserved Domains (1) summary
      COG5415
      Location:10 → 278
      COG5415; Predicted integral membrane metal-binding protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38878.1

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